中国耳鼻咽喉头颈外科2024，Vol.31Issue(6)：369-376,8.DOI:10.16066/j.1672-7002.2024.06.007
鼻黏膜不同炎症的临床表现及客观炎症指标的异同性研究
Study on the clinical manifestations and objective inflammation indicators in patients with different nasal mucosal inflammation
摘要
Abstract
OBJECTIVE To test whether there are some differences among chronic rhinitis,chronic rhinosinusitis patients with nasal polyps(CRSsNP)and without nasal polyps(CRSsNP)in symptom severity,health-related quality-of-life impairment,and objective inflammatory factors.METHODS A total of 154 consecutive patients who had been treated at the Otolaryngology Department of Beijing Tongren Hospital from January 2017 to December 2018 were recruited in this study.The patients aged 18-70 years,with 106 males and 48 females.All patients performed endoscopic examination,nasal exhaled nitric oxide(nNO),skin prick test(SPT),sinus CT scan,complete blood count,and fulfilled the visual analogue scale(VAS)self-assessment of nasal symptoms and the SNOT-22 questionnaire under the guidance of the physician.According to the inclusion criteria,A total of 43 patients with CR,58 patients with CRSsNP and 53 patients with CRSwNP were enrolled in our study.RESULTS The total SNOT-22 score in CRSsNP group was significantly lower than that in CR and CRSwNP groups(30.0±19.4 vs.41.1±21.9,30.0±19.4 vs.40.9±18.7,P<0.05),and there was no significant difference between CR group and CRSwNP group.The average scores of nasal symptoms and extranasal symptoms in CRSwNP group were the highest;the scores in CRSsNP group were lower.The impact of CR patients on sleep damage was significantly higher than that in CRSsNP patients(9.9±6.2 vs.5.1±5.3,P<0.05),and there was no significant difference between CR group and CRSwNP group(9.9±6.2 vs.7.1±5.7,P>0.05).When patients suffered with positive SPT,there was no statistical difference in symptom scores and SNOT-22 scores between CR,CRSsNP,and CRSwNP;but with negative SPT,there was a significant statistical difference in both symptom scores and SNOT-22 scores among the three groups.CONCLUSION CR,CRSsNP and CRSwNP have a significant impact on quality of life,respectively.In terms of symptom scores and quality of life scores,the CR group and CRSwNP group are similar and the scores are higher than that of the CRSsNP group.However,the objective inflammation factors are not consistent with the subjective symptom scores and quality of life scores.关键词
鼻炎/鼻窦炎/鼻息肉/一氧化氮/慢性鼻窦炎不伴鼻息肉/慢性鼻窦炎伴鼻息肉/鼻腔鼻窦结局测试22条/视觉模拟量表Key words
Rhinitis/Sinusitis/Nasal Polyps/Nitric Oxide/chronic rhinosinusitis without nasal polyps/chronic rhinosinusitis with nasal polyps/Sinonasal Outcome Test-22/visual analogue scale引用本文复制引用
刘承耀,王向东,森巴,司马宇彤,刘仲燕,张罗..鼻黏膜不同炎症的临床表现及客观炎症指标的异同性研究[J].中国耳鼻咽喉头颈外科,2024,31(6):369-376,8.基金项目
国家重点研发计划(2022YFC2504100) （2022YFC2504100）
教育部长江学者创新团队(IRT13082) （IRT13082）
中国医学科学院医学与健康科技创新工程项目资助(2019-I2M-5-022) （2019-I2M-5-022）
首都卫生发展科研专项重点攻关项目(2022-1-1091) （2022-1-1091）
