缺血性卒中急性期HALP评分与卒中后认知障碍相关性研究OA北大核心CSTPCD

Objective:In recent years,the HALP score(calculated as the product of hemoglobin,albumin,lymphocytes,and platelets)has gained wide attention as a new indicator for assessing systemic inflammation and nutritional status.This study aims to investigate the relationship between the HALP score and post-stroke cognitive impairment(PSCI)in patients with acute isch-emic stroke(AIS),as well as its predictive value.Methods:A total of 220 AIS patients were enrolled,and their general clinical data were collected.Based on the Montreal Cognitive Assessment(MOCA)scores,patients were categorized into the PSCI and the post-stroke non-cognitive impairment(PSNCI)groups.The HALP score was calculated using the formula:hemoglobin(g/L)×albumin(g/L)×lymphocytes(/L)/platelets(/L),and was divided into three tertiles.Binary logistic regression analysis was employed to explore the association between HALP and cognitive outcomes.Results:The HALP scores were found to be significantly lower in the PSCI group compared to the non-PSCI group(P＜0.001).The HALP scores were divided into three cat-egories:T1≤33.90,T2 33.90～53.75,and T3＞53.75.In the binary logistic regression analysis,after controlling for confound-ing factors,the risk of PSCI was significantly higher in the T1 tertile compared to the T3 tertile(OR=9.38,95%CI=1.93～45.95,P=0.006).However,there was no significant increase in the risk of PSCI in the T2 tertile(OR=1.52,95%CI=0.58～4.02,P=0.393).Conclusion:The HALP score in the acute phase of AIS is associated with PSCI,and furthermore,the HALP score has diagnostic value for PSCI.