海南医学院学报2024，Vol.30Issue(13)：982-989,8.DOI:10.13210/j.cnki.jhmu.20240408.002
缺血性卒中急性期HALP评分与卒中后认知障碍相关性研究
Correlation between HALP score in acute phase of ischemic stroke and post-stroke cognitive impairment
摘要
Abstract
Objective:In recent years,the HALP score(calculated as the product of hemoglobin,albumin,lymphocytes,and platelets)has gained wide attention as a new indicator for assessing systemic inflammation and nutritional status.This study aims to investigate the relationship between the HALP score and post-stroke cognitive impairment(PSCI)in patients with acute isch-emic stroke(AIS),as well as its predictive value.Methods:A total of 220 AIS patients were enrolled,and their general clinical data were collected.Based on the Montreal Cognitive Assessment(MOCA)scores,patients were categorized into the PSCI and the post-stroke non-cognitive impairment(PSNCI)groups.The HALP score was calculated using the formula:hemoglobin(g/L)×albumin(g/L)×lymphocytes(/L)/platelets(/L),and was divided into three tertiles.Binary logistic regression analysis was employed to explore the association between HALP and cognitive outcomes.Results:The HALP scores were found to be significantly lower in the PSCI group compared to the non-PSCI group(P＜0.001).The HALP scores were divided into three cat-egories:T1≤33.90,T2 33.90～53.75,and T3＞53.75.In the binary logistic regression analysis,after controlling for confound-ing factors,the risk of PSCI was significantly higher in the T1 tertile compared to the T3 tertile(OR=9.38,95%CI=1.93～45.95,P=0.006).However,there was no significant increase in the risk of PSCI in the T2 tertile(OR=1.52,95%CI=0.58～4.02,P=0.393).Conclusion:The HALP score in the acute phase of AIS is associated with PSCI,and furthermore,the HALP score has diagnostic value for PSCI.关键词
急性缺血性卒中/HALP评分/卒中后认知障碍/危险因素Key words
Acute ischemic stroke/HALP score/Post-stroke cognitive impairment/Risk factors分类
医药卫生引用本文复制引用
周涛,戴莉莉,宋雨影,卡力比努尔·赛买提,哈斯也提·依不来音..缺血性卒中急性期HALP评分与卒中后认知障碍相关性研究[J].海南医学院学报,2024,30(13):982-989,8.基金项目
This study was supported by Excellent and Suitable Technology Promotion Project for Health and Poverty Alleviation Work in Xinjiang Uygur Autonomous Region Standardization Diagnosis and Treatment Technology Promotion of Alzheimer's Disease in Grassroots Hospitals in Xinjiang(SYTG-Y201934) 新疆维吾尔自治区卫生健康扶贫工作优秀适宜技术推广项目 新疆基层医院阿尔茨海默病的规范化诊治技术推广(SYTG-Y201934) （SYTG-Y201934）
