专职吞噬细胞胞葬功能在慢性创面修复中的作用机制及应用OA北大核心CSTPCD

Chronic wounds,as a long-term wasting disease,are a long-term clinical problem that is difficult to solve.Dysfunc-tion of efferocytosis prevents apoptotic cells from being cleared from the wound in time,resulting in secondary cell necrosis and re-lease of pro-inflammatory cytokines,making it difficult for the wound to transition from the inflammatory phase to the proliferative phase.Macrophages and dendritic cells,as professional phagocytes,are the main bearers of efferocytosis.This article reviews the mechanism of action of these two types of professional phagocytes in the wound healing process and finds that in addition to efferocytosis-related receptors,macrophages and dendritic cells also play a role in cytosis by acting on signaling molecules such as ICAM-1,NK-4,MIR-21,CD36,etc.,to accelerate the healing of chronic wounds.In addition,the efferocytosis function of den-dritic cells may be limited by SLC7A11.Removing or inhibiting SLC7A11 can significantly enhance the efferocytosis of dendritic cells and promote chronic wound healing.This study is of great significance to further elucidating the healing process of chronic re-fractory wound and the development of new treatmentss.