海南医学院学报2024，Vol.30Issue(13)：1035-1040,6.DOI:10.13210/j.cnki.jhmu.20240005.001
专职吞噬细胞胞葬功能在慢性创面修复中的作用机制及应用
The mechanism and application of specialized phagocytic cell burial function in chronic wound repair
摘要
Abstract
Chronic wounds,as a long-term wasting disease,are a long-term clinical problem that is difficult to solve.Dysfunc-tion of efferocytosis prevents apoptotic cells from being cleared from the wound in time,resulting in secondary cell necrosis and re-lease of pro-inflammatory cytokines,making it difficult for the wound to transition from the inflammatory phase to the proliferative phase.Macrophages and dendritic cells,as professional phagocytes,are the main bearers of efferocytosis.This article reviews the mechanism of action of these two types of professional phagocytes in the wound healing process and finds that in addition to efferocytosis-related receptors,macrophages and dendritic cells also play a role in cytosis by acting on signaling molecules such as ICAM-1,NK-4,MIR-21,CD36,etc.,to accelerate the healing of chronic wounds.In addition,the efferocytosis function of den-dritic cells may be limited by SLC7A11.Removing or inhibiting SLC7A11 can significantly enhance the efferocytosis of dendritic cells and promote chronic wound healing.This study is of great significance to further elucidating the healing process of chronic re-fractory wound and the development of new treatmentss.关键词
慢性难愈性创面/皮肤损伤/巨噬细胞/树突状细胞/胞葬作用/炎症消退Key words
Chronic refractory wounds/Skin damage/Macrophages/Dendritic cells/Cellular burial function/Inflammation subsides分类
医药卫生引用本文复制引用
蔺莉,徐旭英..专职吞噬细胞胞葬功能在慢性创面修复中的作用机制及应用[J].海南医学院学报,2024,30(13):1035-1040,6.基金项目
This study was supported by National Natural Science Foundation of China(82174388) （82174388）
Beijing Hundred Million Talents Project Training Fund(2019A30) （2019A30）
the Fifth Batch of National Clinical Outstanding Talents of Traditional Chinese Medicine[National Office of Traditional Chinese Medicine Teaching Letter(2021)No.271] （2021）
Beijing Hospital Management Center"Peak"Talent Training Program(DFL20220801) 国家自然科学基金面上项目(82174388) （DFL20220801）
北京市百千万人才工程培养经费资助(2019A30) （2019A30）
第五批全国中医临床优秀人才[国中医药办人教函(2021)271号] （2021）
北京市医院管理中心"登峰"人才培养计划(DFL20220801) （DFL20220801）
