河南中医2024，Vol.44Issue(6)：935-941,7.DOI:10.16367/j.issn.1003-5028.2024.06.0173
中药复方基于Wnt/β-catenin信号通路调控糖尿病肾病研究进展
Research Progress of Chinese Medicinal Compound Formulas in the Regulation of Diabetes Nephropathy Based on Wnt/β-Catenin Signaling Pathway
摘要
Abstract
Diabetes nephropathy is one of the most common microvascular complications of diabetes,and also the main cause of end-stage renal disease.Wnt/β-catenin signaling pathway is a multifunctional pathway,which is closely related to tubulointerstitial fibrosis in diabetes nephropathy.It mainly improves diabetes nephropathy through podocytes,mesangial cells,tubular epithelial cells,etc.Chi-nese medicinal compound formulas can improve kidney disease and fibrosis by regulating the Wnt/β-catenin signaling pathway,protect kidney function,delay disease progression,and play a role in activating autophagy,reducing inflammatory response,and weakening oxi-dative stress in treatment.At present,research on Chinese medicinal compound formulas based on the Wnt/β-catenin signaling pathway still has the following shortcomings:(1)In the study of Chinese medicinal compound formulas,it can be concluded that they can exert their effects through the Wnt/β-catenin signaling pathway.However,due to the complex and diverse composition of them,most of them only found correlations without analyzing their specific active ingredients;(2)The relevant research on the Wnt/β-catenin signaling pathway has not deeply explored its mechanism of action in renal fibrosis;(3)Most of the current experiments on Chinese medicinal compound formulas are based on in vivo animal experiments,lacking exploration of in vitro cell related experiments.In the future,it is necessary to strengthen the research on the active ingredients of Chinese medicinal compound formulas,and conduct more in vitro cell experiments to conduct in-depth research on the mechanisms of action and targets.关键词
Wnt/β-catenin信号通路/糖尿病肾病/中药复方/通络益肾温阳方/肾衰宁胶囊/糖肾平/固肾泄浊和络方/补阳还五汤/六味地黄丸/芪参益气滴丸/益肾化瘀方分类
医药卫生引用本文复制引用
丁文君,陈彩英,沈明霞,靳锋..中药复方基于Wnt/β-catenin信号通路调控糖尿病肾病研究进展[J].河南中医,2024,44(6):935-941,7.基金项目
甘肃省自然科学基金项目(20JR10RA342,22JR5RA642) （20JR10RA342,22JR5RA642）
甘肃省名中医传承工作室建设项目{甘卫中医函[2023]62号} （）
