中药复方基于Wnt/β-catenin信号通路调控糖尿病肾病研究进展OA

Diabetes nephropathy is one of the most common microvascular complications of diabetes,and also the main cause of end-stage renal disease.Wnt/β-catenin signaling pathway is a multifunctional pathway,which is closely related to tubulointerstitial fibrosis in diabetes nephropathy.It mainly improves diabetes nephropathy through podocytes,mesangial cells,tubular epithelial cells,etc.Chi-nese medicinal compound formulas can improve kidney disease and fibrosis by regulating the Wnt/β-catenin signaling pathway,protect kidney function,delay disease progression,and play a role in activating autophagy,reducing inflammatory response,and weakening oxi-dative stress in treatment.At present,research on Chinese medicinal compound formulas based on the Wnt/β-catenin signaling pathway still has the following shortcomings:(1)In the study of Chinese medicinal compound formulas,it can be concluded that they can exert their effects through the Wnt/β-catenin signaling pathway.However,due to the complex and diverse composition of them,most of them only found correlations without analyzing their specific active ingredients;(2)The relevant research on the Wnt/β-catenin signaling pathway has not deeply explored its mechanism of action in renal fibrosis;(3)Most of the current experiments on Chinese medicinal compound formulas are based on in vivo animal experiments,lacking exploration of in vitro cell related experiments.In the future,it is necessary to strengthen the research on the active ingredients of Chinese medicinal compound formulas,and conduct more in vitro cell experiments to conduct in-depth research on the mechanisms of action and targets.