环状RNA在系统性红斑狼疮中的潜在应用研究进展OACSTPCD

Circular RNA(circRNA),formed by reverse splicing of pre-mRNA,constitutes a closed-loop RNA structure with diversity in molecular characteristics,biological functions,and regulatory mechanisms.In recent years,there has been growing recognition of the roles of circRNA in various human diseases,serving potentially as molecular biomarkers for disease diagnosis and prognosis prediction,including the classical autoimmune disease systemic lupus erythematosus(SLE).Currently,dysregulated expression of some circRNAs has been observed in SLE,which can promote the occurrence and development of SLE through different mechanisms such as"molecular sponge"effects,modulation of signaling pathways,inhibition of protein kinase activation,and induction of cell apoptosis.Another part may serve as potential clinical biomarkers for SLE,holding translational potential.This paper reviews the research on circRNA in SLE over the past years,aiming to provide scientific evidence and references for subsequent studies on circRNA in SLE.