昆明医科大学学报2024，Vol.45Issue(6)：161-165,5.DOI:10.12259/j.issn.2095-610X.S20240622
环状RNA在系统性红斑狼疮中的潜在应用研究进展
Research Progress on The Potential Application of Circular RNA in Systemic Lupus Erythematosus
摘要
Abstract
Circular RNA(circRNA),formed by reverse splicing of pre-mRNA,constitutes a closed-loop RNA structure with diversity in molecular characteristics,biological functions,and regulatory mechanisms.In recent years,there has been growing recognition of the roles of circRNA in various human diseases,serving potentially as molecular biomarkers for disease diagnosis and prognosis prediction,including the classical autoimmune disease systemic lupus erythematosus(SLE).Currently,dysregulated expression of some circRNAs has been observed in SLE,which can promote the occurrence and development of SLE through different mechanisms such as"molecular sponge"effects,modulation of signaling pathways,inhibition of protein kinase activation,and induction of cell apoptosis.Another part may serve as potential clinical biomarkers for SLE,holding translational potential.This paper reviews the research on circRNA in SLE over the past years,aiming to provide scientific evidence and references for subsequent studies on circRNA in SLE.关键词
环状RNA/系统性红斑狼疮/生物标志物/分子机制Key words
Circular RNA/Systemic lupus erythematosus/Biomarkers/Molecular mechanisms分类
医药卫生引用本文复制引用
李力,张瑞仙..环状RNA在系统性红斑狼疮中的潜在应用研究进展[J].昆明医科大学学报,2024,45(6):161-165,5.基金项目
国家自然科学基金资助项目(82060305) （82060305）
