中国骨伤2024，Vol.37Issue(6)：565-570,6.DOI:10.12200/j.issn.1003-0034.20221194
血清HDL/LDL和t-PINP/β-CTX与老年女性骨质疏松性椎体骨折相关性研究
Correlation between serum HDL/LDL and t-PINP/β-CTX and osteoporotic vertebral fractures in elderly women
摘要
Abstract
Objective To explore high density lipoprotein(HDL)/low density lipoprotein(LDL)and total type Ⅰ collagen amino terminal extender peptide(t-PINP)/C-terminal peptide of type Ⅰ collagen β special sequence(β-CTX)and risk of os-teoporosis vertebral fractures(OPVFs)in elderly women.Methods The clinical data of 446 female OPVFs patients aged above 60 years old from January 2019 to December 2020 were retrospectively analyzed.According to whether or not fracture,patients were divided into non-fracture group(186 patients)and fracture group(260 patients).Univariate analysis was performed to analysis age,body mass index(BMI),N-terminal mioldle molecular fragment of osteocalcin,N-MID OC),t-PINP,β-CTX,25-hydroxyvitamin D[25-(OH)VitD],blood sugar(Glu),total cholesterol(TC),high-density lipoprotein(HDL),low-density lipoprotein(LDL),Ca,P,Mg,urea(UREA),creatinine(Cr)and Cystatin C(CysC),and correlation between OPVFs and the above indexes and lipid,bone metabolism indexes between two groups;Logistic regression was performed to analyze risk factors and stratification relationship between vertebral fracture and HDL/LDL,t-PINP/β-CTX.Logistic regression was used to ana-lyze risk factors and stratification relationship between OPVFs and HDL/LDL,t-PINP/β-CTX.Results There were no signif-icant difference in age and BMI between non-fracture group and fracture group(P＞0.05).Compared with non-fracture group,contents of HDL,t-PINP/β-CTX and HDL/LDL in fracture group were decreased,and contents of β-CTX were increased(P＜0.05).OPVFs was positively correlated with β-CTX(r=0.110,P＜0.05),and negatively correlated with HDL,HDL/LDL and t-PINP/β-CTX(r=-0.157,-0.175,-0.181,P＜0.05).HDL and HDL/LDL were negatively correlated with β-CTX(r=-0.22,-0.12,P＜0.05)and t-PINP(r=-0.13,-0.10,P＜0.05).25-(OH)VitD was positively correlated with TC and HDL(r=0.11,0.18,P＜0.05).HDL/LDL was positively correlated with t-PINP/β-CTX(r=0.11,P=0.02).t-PINP/β-CTX[OR=0.998,95％CI(0.997,1.000),P＜0.05],HDL/LDL[OR=0.228,95％CI(0.104,0.499),P＜0.01]were risk factors for vertebral fracture.The lower levels between two tristratified indicators,the higher the vertebral fracture rate.The risk of fracture was 2.5 and 2 times higher in the lowest stratum than in the highest stratum,with an adjusted OR was[2.112,95％CI(1.310,3.404)]and[2.331,95％CI(1.453,3.739)],respectively.Conclusion Serum low HDL/LDL and t-PINP/β-CTX are independent risk factors for OPVF in elderly women,and have good predictive value for OPVF risk.关键词
老年女性/骨质疏松/椎体骨折Key words
Elderly women/Osteoporosis/Vertebral fracture分类
医药卫生引用本文复制引用
桑阳,邹明,岳建彪..血清HDL/LDL和t-PINP/β-CTX与老年女性骨质疏松性椎体骨折相关性研究[J].中国骨伤,2024,37(6):565-570,6.基金项目
四川省干部保健科研课题(编号:川干研2019-605)Sichuan Cadre Health Research Project(No.Chuanganyan 2019-605) （编号:川干研2019-605）
