单纯形重心法复配多糖/纳米纤维素水凝胶OA

In this study,sodium alginate(SA),xanthan gum(XAN),gelatin(G),and nanocellulose(NC)were utilized as encapsulating materials.The simplex barycenter method was employed to optimize the formulation through experimental design.The morphology,texture properties,pH sensitivity and Fourier transform infrared spectroscopy(FT-IR)of the hydrogels were analyzed.The results indicated that the addition of NC increased the viscosity of the hydrogel blend solution,improved the apparent morphology and enhanced the textural properties of the hydrogel,FT-IR showed good compatibility between NC and the polysaccharides.Furthermore,the inclusion of NC increased the swelling ratio of the hydrogel.The polysaccharide/nanocellulose composite hydrogel exhibited excellent pH sensitivity.The theoretical optimal composition was obtained through the simplex barycenter method(SA 19.25%;XAN 24.10%;G 41.00%;NC 15.65%).In conclusion,the final work used the simplex barycenter method to prepare the nanogel with excellent pH sensitivity,capable of stable passage through simulated gastric environments.This provides foundational data for the encapsulation of aerobic probiotics in composite hydrogels and offers a reference for further research and application of hydrogel delivery systems.