中国兽医科学2024，Vol.54Issue(7)：955-961,7.DOI:10.16656/j.issn.1673-4696.2024.0123
大肠杆菌表达动物病毒样颗粒疫苗的研究进展
Research progress of animal virus-like particles vaccine expressed by Escherichia coli
摘要
Abstract
The Escherichia coli expression system is widely employed for heterologous protein ex-pression due to its numerous advantages,including high expression yield,short production cycle,and low cost.It has been reported that more than 30％of recombinant protein drugs and 50％of recombinant protein preparations utilize Escherichia coli as the preferred host organism.consequently,Es-cherichia coli holds significant importance in the economical production of veterinary vaccines.This paper provides a comprehensive overview of the production and research advancements in utilizing the Escherichia coli expression system for animal virus-like particle vaccine applications.Furthermore,it summarizes the current challenges faced by this system in vaccine development along with potential solutions,aiming to offer valuable insights for future studies on animal virus-like particle vaccines employing Escherichia coli as an expression host.关键词
大肠杆菌/表达宿主/病毒样颗粒疫苗Key words
Escherichia coli/expression host/virus-like particle vaccine分类
农业科技引用本文复制引用
李幽幽,扶星星,朱玲,王永胜,吴福文,张海,徐志文..大肠杆菌表达动物病毒样颗粒疫苗的研究进展[J].中国兽医科学,2024,54(7):955-961,7.基金项目
国家农业产业技术体系四川兽药创新团队专项(CARS-SVDIP) （CARS-SVDIP）
四川省"十四五"川猪重大科技专项(2021ZDZX0010-3) （2021ZDZX0010-3）
