绒促性素结合针灸对多囊卵巢综合征患者性激素水平及排卵率的影响OA
Effect of Chorionic Gonadotropin Combined with Acupuncture on Hormonal Levels and Ovulation Rates in Patients with Polycystic Ovary Syndrome
目的:探究绒促性素结合针灸对多囊卵巢综合征患者性激素水平及排卵率的影响.方法:选取瑞金市妇幼保健院 2021 年 10 月—2022 年 9 月诊治的 78 例多囊卵巢综合征患者作为研究对象,随机分为对照组(39 例)和观察组(39 例).对照组采取口服枸橼酸氯米芬片和炔雌醇环丙孕酮片治疗,观察组在口服枸橼酸氯米芬片的基础上,联合使用针灸和绒促性素治疗.治疗 3 个月后,比较两组性激素[雌二醇(E2)、睾酮(T)、黄体生成素(LH)和卵泡刺激素(FSH)]、卵巢体积、子宫内膜厚度、宫颈黏液评分、卵泡直径(FD)≥12 mm卵泡数和最大FD,记录并比较两组排卵、妊娠情况、不良反应发生情况.结果:治疗后,观察组血清E2 水平为(111.32±33.41)pmol/L,高于对照组的(96.59±26.51)pmol/L,且两组均高于治疗前,差异均有统计学意义(P<0.05).治疗后,观察组LH、FSH、T水平分别为(8.87±2.24)U/L、(5.22±1.19)U/L和(1.38±0.50)pmol/L,均 低 于 对 照 组 的(15.14±3.21)U/L、(8.03±1.47)U/L和(1.87±0.48)pmol/L,且两组均低于治疗前,差异均有统计学意义(P<0.05).治疗后,观察组卵巢体积(12.27±2.06)mL,子宫内膜厚度(10.73±0.93)mm,宫颈黏液评分(9.81±2.93)分,均优于对照组[(10.84±2.12)mL、(8.34±1.04)mm、(7.24±2.86)分](P<0.05).治疗后,观察组FD≥12 mm卵泡数和最大FD分别为(8.21±1.58)个和(21.30±2.31)mm,均优于对照组[(5.64±1.12)个,(17.26±2.44)mm],差异均有统计学意义(P<0.05).观察组排卵率和妊娠率分别为 92.31%(36/39)和 53.85%(21/39),均显著高于对照组[69.23%(27/39)和 23.08%(9/39)],差异均有统计学意义(P<0.05).两组不良反应发生率比较,差异无统计学意义(P>0.05).结论:绒促性素结合针灸能够有效改善多囊卵巢综合征患者性激素水平,提高排卵率和妊娠率.
Objective:To explore the effects of Chorionic Gonadotropin combined with acupuncture on hormone levels and ovulation rates in patients with polycystic ovary syndrome(PCOS).Method:A total of 78 PCOS patients treated at Ruijin Maternal and Child Health Care Hospital from October 2021 to September 2022 were selected as research subjects,they were randomly divided into a control group(39 cases)and an observation group(39 cases).The control group was treated with oral Clomiphene Citrate Tablets and Ethinylestradiol Cyproterone Tablets,while the observation group was treated with acupuncture and Chorionic Gonadotropin on the basis of Clomiphene Citrate Tablets.Sex hormones[estradiol(E2),testosterone(T),luteinizing hormone(LH),and follicle stimulating hormone(FSH)],ovarian volume,endometrial thickness,cervical mucus score,number of follicles with a diameter(FD)≥12 mm,and the maximum FD of the two groups were compared,ovulation and pregnancy rates,and the incidence of adverse reactions were recorded and compared between the groups.Result:After treatment,the serum E2 level in the observation group was(111.32±33.41)pmol/L,which was higher than(96.59±26.51)pmol/L in the control group,those in both groups were higher compared to those before treatment,the differences were statistically significant(P<0.05).After treatment,the levels of LH,FSH,and T in the observation group were(8.87±2.24)U/L,(5.22±1.19)U/L,and(1.38±0.50)pmol/L,respectively,all lower than(15.14±3.21)U/L,(8.03±1.47)U/L,and(1.87±0.48)pmol/L in the control group,those in both groups were lower compared to those before treatment,the differences were statistically significant(P<0.05).After treatment,the ovarian volume(12.27±2.06)mL,endometrial thickness(10.73±0.98)mm,and cervical mucus score(9.81±2.93)points in the observation group,all were better than(10.84±2.12)mL,(8.34±1.04)mm,(7.24±2.86)points in the control group,the differences were statistically significant(P<0.05).After treatment,the number of follicles(FD)≥12 mm and the maximum FD in the observation group were(8.21±1.58)and(21.30±2.31)mm,respectively,which were better than(5.64±1.12),(17.26±2.44)mm in the control group,the differences were statistically significant(P<0.05).The ovulation and pregnancy rates in the observation group were 92.31%(36/39)and 53.85%(21/39),respectively,significantly higher than 69.23%(27/39)and 23.08%(9/39)in the control group,the differences were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion:Chorionic Gonadotropin combined with acupuncture can effectively improve the hormonal levels,and increase the ovulation and pregnancy rates in patients with PCOS.
刘琼;陈蕾;刘流山
瑞金市妇幼保健院妇科 江西 瑞金 342500瑞金市妇幼保健院中医科 江西 瑞金 342500
绒促性素针灸多囊卵巢综合征性激素促排卵
Chorionic GonadotropinAcupuncturePolycystic ovary syndromeHormonesOvulation induction
《中国医学创新》 2024 (017)
75-80 / 6
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