中国中医药信息杂志2024，Vol.31Issue(7)：14-19,6.DOI:10.19879/j.cnki.1005-5304.202308012
基于中医阴阳理论探讨肿瘤相关巨噬细胞极化在肺癌中的作用
Discussion on the Effects of Tumor-associated Macrophages Polarization on Lung Cancer Based on the TCM Yin-yang Theory
摘要
Abstract
Lung cancer is the cancer type with the highest incidence rate and mortality among malignant tumors in China.Tumor associated macrophages(TAMs)are closely related to the occurrence,development,invasion and metastasis,and treatment tolerance of lung cancer.This article explored the etiology and pathogenesis of lung cancer in TCM,as well as the key role of TAMs in lung cancer.It was found that the local imbalance of yin and yang in TAMs,as well as the overall imbalance of yin and yang in the tumor microenvironment and whole body,were important reasons for the formation and progression of lung cancer.In the progression and sequelae of lung cancer,M1 and M2 type TAMs each plays different roles and has different yin and yang properties.Both of them maintain a constantly developing and changing state of mutual use,opposing constraints,and balance of growth and decline.Based on the yin-yang theory in TCM,according to the progression of lung cancer and the imbalance of yin and yang,rational selection and medication can adjust the phenotype of TAMs,promote the overall balance of yin and yang,and provide reference for the clinical prevention and treatment of lung cancer.关键词
肿瘤相关巨噬细胞/表型/阴阳平衡/肺癌Key words
tumor-associated macrophages/phenotype/balance of yin and yang/lung cancer分类
医药卫生引用本文复制引用
王玉,张露,黄思敏,于东东,汤磊磊,陆婷婷..基于中医阴阳理论探讨肿瘤相关巨噬细胞极化在肺癌中的作用[J].中国中医药信息杂志,2024,31(7):14-19,6.基金项目
国家自然科学基金青年基金(82104454) （82104454）
安徽省自然科学基金青年基金(2108085QH376) （2108085QH376）
安徽省高校优秀拔尖人才培育资助项目(gxyq2020018) （gxyq2020018）
安徽中医药大学高层次人才支持计划项目(2021rcyb009) （2021rcyb009）
安徽高校研究生科学研究项目(YJS20210482) （YJS20210482）
安徽省新时代育人质量工程项目(研究生教育)(2022xscx105) （研究生教育）
安徽中医药大学大学生创新创业训练计划(202110369041) （202110369041）
