中国肿瘤生物治疗杂志2024，Vol.31Issue(6)：541-551,11.DOI:10.3872/j.issn.1007-385x.2024.06.001
肿瘤免疫治疗新视角:RUNX的作用与意义
A new perspective on tumor immunotherapy:the role and significance of RUNX
摘要
Abstract
RUNX,a member of transcription factor family,plays an important role in the regulation of mammalian cell proliferation,differentiation,lineage development,osteogenesis and neurogenesis.The studies of RUNX have revealed the diversity of its function and its role in tumor genesis and progression.RUNX family members have different functional manifestations in different types of tumors and have different levels of association with various components in the tumor microenvironment.RUNX family members regulate the lineage development and differentiation of CD4+helper T(Th)cells and CD8+cytotoxic T lymphocytes(CTLs)in the tumor microenvironment,modulate the phenotype,differentiation,and survival of tissue-resident T-lymphocytes,and drive the proliferation activation and tissue-resident of NK-cells.RUNX family deletion leads to MDSC proliferation and maturation activation,which induces a tumor immunosuppressive microenvironment.The expression of RUNX family members also significantly correlates with the degree of infiltration of tumor-associated fibroblasts(CAFs)in the tumor microenvironment,the infiltration of different immune cells,immune checkpoint gene expression,and drug sensitivity,which could serve as potential prognostic markers of tumors and as targets for tumor immunotherapy,and the combination with CAR-T cell therapy has great potential for application.This review focuses on the basic structure and function of RUNX and its role in the regulation of various components in tumor immunity and microenvironment,aiming to provide a new perspective for tumor immunotherapy with RUNX as the main target in the future.关键词
RUNX/肿瘤微环境/免疫细胞/生物学功能Key words
RUNX/tumor microenvironment(TME)/immunocyte/biological function分类
医药卫生引用本文复制引用
刘颖婷,蒋敬庭..肿瘤免疫治疗新视角:RUNX的作用与意义[J].中国肿瘤生物治疗杂志,2024,31(6):541-551,11.基金项目
国家自然科学基金(No.32270955,No.81972869) （No.32270955,No.81972869）
江苏省重点研发计划专项资金项目(No.BE2022719) （No.BE2022719）
江苏省自然科学基金(No.BK20211065) （No.BK20211065）
江苏省医学重点学科基金(No.YXZDXK202236) （No.YXZDXK202236）
江苏省研究生科研与实践创新计划(No.KYCX23_3265) （No.KYCX23_3265）
常州市卫生健康委员会重大科技项目(No.ZD202329) （No.ZD202329）
常州市卫生健康委员会青苗工程项目(No.CZQM2020044) （No.CZQM2020044）
