海南医学院学报2024，Vol.30Issue(14)：1104-1110,7.DOI:10.13210/j.cnki.jhmu.20240228.001
Wnt/β-catenin通路调控铁死亡在肝癌中的研究进展
Wnt/β-catenin pathway regulates iron death in hepatocellular carcinoma
摘要
Abstract
Iron death is considered to be an iron-dependent,non-apoptotic form of regulated cell death,which is mainly trig-gered by reactive oxygen species(ROS)production and imbalance of iron homeostasis leading to severe lipid peroxidation,and it induces related factors that can directly or indirectly affect glutathione peroxidase through different pathways,leading to decreased antioxidant capacity and accumulation of lipid reactive oxygen species(ROS)in the cells,and ultimately leading to oxidative cell death.Meanwhile,iron death is regulated by various pathways,such as iron metabolism,mitochondrial activity,redox homeosta-sis,and disease-related signalling pathways.It has been reported that dysregulation of iron death metabolic pathways can affect the development and progression of hepatocellular carcinoma.Little is known about the molecular mechanisms by which iron death leads to disease,but iron death-related genes and pathways are associated with hepatocellular carcinoma progression.It was found that abnormal activation of the Wnt/β-catenin signalling pathway is associated with recurrence,invasion,metastasis and immune escape of hepatocellular carcinoma,and is closely linked to iron death.This pathway can further aggravate the progression of hepa-tocellular carcinoma by regulating the occurrence of iron death.Some substantial progress has been made in this field in hepatocellu-lar carcinoma.Therefore,in the present review,we will explore the process of iron death by outlining its molecular mechanism and its role in hepatocellular carcinoma,and at the same time,we will specifically analyse the Wnt/β-catenin signaling pathway to regulate the process of iron death,so as to provide a reliable scientific theoretical basis for the treatment of hepatocellular carcino-ma in the future.关键词
Wnt/β-catenin信号通路/铁死亡/肝癌/侵袭/转移/免疫逃逸Key words
Wnt/β-catenin signalling pathway/Iron death/Hepatocellular carcinoma/Invasion/Metastasis/Immune escape分类
医药卫生引用本文复制引用
陈锦浩,曹智,陈家诚,郑进方..Wnt/β-catenin通路调控铁死亡在肝癌中的研究进展[J].海南医学院学报,2024,30(14):1104-1110,7.基金项目
Hainan Province Key R&D Plan(ZDYF2020134) （ZDYF2020134）
Key R&D project in Hainan Province(ZDYF2022SHFZ131) （ZDYF2022SHFZ131）
Hainan Clinical Medical Research Center Project(LCYX202208)海南省重点研发计划(ZDYF2020134) （LCYX202208）
海南省重点研发项目(ZDYF2022SHFZ131) （ZDYF2022SHFZ131）
海南省临床医学研究中心项目(LCYX202208) （LCYX202208）
