TBI后应激性肠屏障损害的研究进展OA北大核心CSTPCD

Stress induced intestinal barrier damage after traumatic brain injury significantly increases the risk of mortality in pa-tients and seriously affects disease prognosis.However,the pathogenesis and treatment strategies are still not fully understood.This article aims to summarize the research progress on key issues such as the pathological mechanism and protective strategies of stress induced intestinal barrier damage in traumatic brain injury,it points out that increased permeability of intestinal epithelial cells,tight junctions,endoplasmic reticulum stress,autophagy,and ischemia-reperfusion injury may be the main mechanisms of intestinal barrier damage after traumatic brain injury.This article reviews the protective effects of vagus nerve stimulation,probiot-ics,exogenous supplementation of hunger hormone,and oxygen therapy on stress induced intestinal barrier damage after traumatic brain injury.This article will provide a new perspective and intervention targets for exploring precise and effective prevention and treatment of stress induced intestinal barrier damage after traumatic brain injury.