江西农业大学学报2024，Vol.46Issue(3)：691-700,10.DOI:10.3724/aauj.2024062
蛋鸡产蛋前用药后氟苯尼考在鸡蛋中的残留代谢规律研究
Residue depletion of florfenicol in eggs after oral administration to laying hens before laying
摘要
Abstract
[Objective]To explore the withdrawal time of veterinary drugs in laying hens before laying,the accumulation and elimination of florfenicol in eggs of laying hens were examined after oral administration to laying hens before laying,and results can provide scientific support for laying hens breeding industry.[Method]378 healthy Lehmann Pink hens were orally administrated with florfenicol at a therapeutic dose,and the florfenicol and florfenicol amine residues in egg samples were determined by liquid chromatography-tandem mass spectrometry.The withdrawal time of florfenicol in laying hens before laying was determined by using the residue elimination model and software WT1.4.[Result]Results showed that the total residues of florfenicol and florfenicol amine in eggs were gradually increased during administration and reached the peak value(about 307.64 μg/kg)1 d after the drug was stopped,and then the drug residues were gradually decreased with the extension of drug withdrawal time.After 10-day withdrawal time,the total residues of florfenicol and its metabolites in eggs decreased to below the maximum residue limit(MRL)of 10 μg/kg and eventually belowed the detection limit on day 12 post-treatment.Based on the drug residue elimination model and software WT1.4,the withdrawal times of 9.70 d and 10.26 d for florfenicol were acquired.Verification results showed that the total concentrations of florfenicol and florfenicol amine residues in all egg samples belowed 10 μg/kg after 9-day withdrawal time.Based on above results,a 10-day safety interval was recommended for florfenoicol in laying hens before laying.The time interval from the first egg production to the theoretical laying time was 32 d during the experiment period.[Conclusion]Due to the irregularity of eggs production during early laying period,a 42-day withdrawal time is recommended for the florfenicol powder in laying hens before laying,to protect the health of egg consumers.关键词
氟苯尼考/氟苯尼考胺/残留/产蛋前/鸡蛋Key words
florfenicol/florfenicol amine/residue/before laying period/eggs分类
农业科技引用本文复制引用
张莉,董一帆,袁丽娟,向建军,廖且根,邱素艳,张大文..蛋鸡产蛋前用药后氟苯尼考在鸡蛋中的残留代谢规律研究[J].江西农业大学学报,2024,46(3):691-700,10.基金项目
国家农产品质量安全风险评估专项(GJFP2019024,GJFP20230304)和江西省主要学科学术和技术带头人培养计划——领军人才项目(20213BCJ22008)Project supported by the National Agricultural Product Quality and Safety Risk Assessment Project(GJFP2019024,GJFP20230304)and the Training Program for Academic and Technical Leaders of Major Disciplines in Jiangxi Province(20213BCJ22008)江西省农业科学院基础研究与人才培养专项(JXSNKYJCRC202201)同时对本研究给予了资助,谨致谢意! （GJFP2019024,GJFP20230304）
