昆明医科大学学报2024，Vol.45Issue(7)：140-147,8.DOI:10.12259/j.issn.2095-610X.S20240721
综合治疗方案对PCOS不孕患者miR-320、miR-27a及妊娠结局的影响
Effect of Comprehensive Treatment on MiR-320,MiR-27a and Pregnancy Outcome in Infertile Patients with Polycystic Ovary Syndrome
摘要
Abstract
Objective To observe the effect of comprehensive treatment on reproductive hormones,MicroRNA(miRNA)and prognosis of infertile women with polycystic ovary syndrome(PCOS).Methods A total of 120 infertile PCOS patients admitted to Jiangmen Central Hospital hospital from July 2020 to July 2022 were randomly divided into 3 groups,40 cases in each group.The control A group took medication(estrogen+clomiphene+metformin),the control B group took physical and mental interventions(diet+exercise+psychology),and the composite treatment group took a comprehensive treatment program(medication+physical and mental interventions),the intervention lasted for 6 consecutive courses.The prognosis of the three groups was statistically analyzed,as well as their psychological status before and after intervention[The Positive and Negative Affect Scale(PANAS)],miR-320 expression,miR-27a expression,body mass index(BMI),inhibin B(IHNB),hip circumference,anti-Mullerian hormone(AMH),waist circumference,luteinizing hormone/follicle stimulating hormone(LH/FSH).Results Comparison of positive emotion scores in the PANAS scale of three groups after three and six courses of intervention:composite treatment group>control group B>control group A;comparison of negative emotion scores:composite treatment group<control group B<control group A(P<0.05);comparison of miR-320 levels among three groups after three and six courses of intervention:composite treatment group>control group A>control group B,comparison of miR-27a,LH/FSH,IHNB,and AMH levels:composite treatment group<control group A<control group B(P<0.05);after 3 and 6 courses of intervention,the waist circumference,BMI,and hip circumference of the combined treatment group were all smaller than those of the control group A and control group B,and the clinical pregnancy rate was 55.00%,which was higher than the 32.50%of the control group A and the 27.50%of the control group B(P<0.05),however,there was no statistically significant difference between the control groups A and B(P>0.05).Conclusion The comprehensive treatment program applied to PCOS infertility patients has a precise effect,which can promote the balance of hormone metabolism,regulate microRNA expression,reduce obesity,improve menstruation,enhance the pregnancy rate,and also improve the patient's emotional state.关键词
PCOS/不孕/microRNA/激素/代谢Key words
PCOS/Infertility/microRNA/Hormones/Metabolism分类
临床医学引用本文复制引用
何珊,乐爱文,邱杨,甄波,王中海..综合治疗方案对PCOS不孕患者miR-320、miR-27a及妊娠结局的影响[J].昆明医科大学学报,2024,45(7):140-147,8.基金项目
广东省高等职业院校医药卫生类专业教学指导委员会教学改革课题立项项目(2022LX051) （2022LX051）
