生命科学研究2024，Vol.28Issue(3)：189-197,214,10.DOI:10.16605/j.cnki.1007-7847.2023.07.0175
雌激素在疾病性别差异中的作用及机制研究进展
Research Progress of Estrogen in Regulating Gender Differences in Disease
摘要
Abstract
There are many differences between men and women in terms of chromosome composition,body structure,metabolic processes,and hormone types and levels,which make different genders show different physiological responses to diseases and produce very distinct pathological outcomes.More and more studies have confirmed that estradiol,the most important estrogen secreted by the ovary,not only participates in the maintenance of secondary sexual characteristics,but also plays an important role in the gender differences of various diseases.This article systematically discussed the mechanism of estradiol and its receptors as well as the effects of estradiol on immune diseases and trained immunity,and also reviewed the latest research progress of estradiol in other important diseases such as tumors.The study of estradiol can help us better un-derstand the causes of gender differences in immune diseases,and provide new ideas and targets for disease prevention and treatment.It is also of great significance for in-depth understanding of human pathophysiology and improvement of clinical disease treatment.关键词
性别差异/雌二醇(E2)/免疫/疾病Key words
gender difference/estradiol(E2)/immunity/disease分类
生物科学引用本文复制引用
曲俊星,李培志,孙志恒..雌激素在疾病性别差异中的作用及机制研究进展[J].生命科学研究,2024,28(3):189-197,214,10.基金项目
2022年国家自然科学基金青年科学基金项目(32200714) （32200714）
2022年河南师范大学科研启动项目(20220099) （20220099）
2022年新乡医学院科研启动项目(505501) （505501）
2024年河南省自然科学基金项目(242300421535) （242300421535）
