食品工业科技2024，Vol.45Issue(14)：352-360,9.DOI:10.13386/j.issn1002-0306.2023110015
刺梨多酚提取物对高脂饮食诱导的肥胖小鼠的改善作用
Ameliorating Effect of Polyphenol Extract of Rosa roxburghii on Obese Mice Induced by High Fat Diet
摘要
Abstract
Objective:To investigate the beneficial effects of phenolic extracts of Rosa roxburghii Tratt.on obese mice induced by a high-fat diet.Methods:The intervention involved administering polyphenol extract at a dose of 400 mg/kg body weight per day to mice on a high-fat diet.The mice were orally gavaged continuously for 4 weeks,and various parameters such as body weight,liver index,histomorphological changes in white fat and liver tissues,serum biochemical markers,organ antioxidant capacity,and intestinal barrier function were examined.Results:In comparison to control group(CON),the MODEL group(MODEL)exhibited significantly(P＜0.05,P＜0.01)increased the level of insulin and inflammatory factors.The levels of high-density lipoprotein cholesterol(HDL-C)decreased in the four blood lipids,while the levels of total cholesterol(TC),triglycerides(TG),and low-density lipoprotein cholesterol(LDL-C)significantly increased(P＜0.01).The activities of superoxide dismutase(SOD)and glutathione peroxidase(GPx)in antioxidants were significantly reduced(P＜0.01),the expression levels of intestinal barrier proteins and short chain fatty acids(SCFAs)were significantly reduced(P＜0.01).In comparison to MODEL group,the polyphenol intervention groups(RF and RP)showed significantly decreased levels of inflammatory factors and oxidative stress(P＜0.05,P＜0.01),The activity of antioxidant SOD and GPx in the RF group was significantly increased,and the levels of ZO-1,Claduin-1,and SCFAs in the gut of both the RF and RP groups were significantly reversed(P＜0.01).Conclusion:Prickly pear polyphenol extract effectively alleviated metabolic disorders in high-fat diet-induced obese mice in vivo,resulting in reduced body weight gain,protection against cellular changes in adipose and hepatic tissues,alleviation of inflammation and oxidative stress,and enhanced intestinal barrier function.Notably,the RF group showed a superior effect to the RP group.关键词
刺梨多酚提取物/肥胖小鼠/血脂/炎症因子/短链脂肪酸Key words
phenolic extracts of Rosa roxburghii Tratt./obese mice/lipids/inflammatory factors/short-chain fatty acids分类
轻工纺织引用本文复制引用
罗婧文,张欣,王辉,龙明秀,陈朝军,陈中爱,王梅..刺梨多酚提取物对高脂饮食诱导的肥胖小鼠的改善作用[J].食品工业科技,2024,45(14):352-360,9.基金项目
贵州省科技厅科技支撑项目(黔科合支撑[2022]一般149 （）
黔科合支撑[2021]一般116 （）
黔科合支撑[2020]1Y155号) （）
贵州省科技厅2023年度贵州省基础研究计划(黔科合基础-ZK[2023]一般182). （黔科合基础-ZK[2023]一般182）
