国家专利数据库中治疗少弱精子症的中药规律研究OA

Objective To explore the compatibility patterns of traditional Chinese medicine compound formulas for treating oligoasthenospermia in the national patent database,so as to provide reference for the treatment and development of new drugs for oligoasthenospermia.Methods Patent data on traditional Chi-nese medicine compounds for treating oligoasthenospermia from the"China Patent Publication and Announce-ment Website"from January 1,2000,to October 1,2023 were retrieved.The traditional Chinese medicine data-base was established using Excel12.1.0,and the frequency of traditional Chinese medicine use of the included traditional Chinese medicine compounds was analyzed based on the data mining function in the cloud platform of ancient and modern medical records(V2.3.7).On this basis,the traditional Chinese medicine flavor reduc-tion and efficacy analysis were carried out,the core drug pair was screened through drug association analysis,the drug classification of traditional Chinese medicine compounds for the treatment of oligoasthenospermia was obtained through cluster analysis,and the core prescription of traditional Chinese medicine for the treat-ment of oligoasthenospermia was screened through complex network analysis.Results A total of 189 tradi-tional Chinese medicine compounds formulas meeting the criteria were included,involving 280 herbs,with a total frequency of use of 2 305 times.The most frequently used herbs were Cuscuta chinensis,Lycium barba-rum,Epimedium brevicornum,Angelica sinensis,and Rubus chingii.In terms of herbal properties,warm herbs were predominant,with a sweet taste,mainly attributed to the kidney,liver,and spleen meridians.The efficacy of traditional Chinese medicine,such as strengthening tendons and bones and tonifying kidney yang,had rela-tively high frequencies of use.Core herb pairs identified through drug association analysis included"Lycium barbarum-Cuscuta chinensis"and"Cuscuta chinensis-Epimedium brevicornum."Cluster analysis grouped 22 high-frequency Chinese herbs(＞25 times of use)into five categories.Complex network analysis identified"Wuzi Yanzong Pill"as the core formula for treating oligoasthenospermia with modifications.Conclusion Traditional Chinese medicine treatment for oligoasthenospermia primarily targets the core pathological mechanism of"kidney qi deficiency and kidney essence insufficiency",focusing on"tonifying the kidney to nourish essence"as the core therapeutic principle.Emphasis is placed on regulating the kidneys,liver,and spleen,with commonly used herbs including those that strengthen tendons and bones and tonify kidney yang.The core prescription identi-fied is composed of"Wuzi Yanzong Pill"with modifications.