中国临床医学2024，Vol.31Issue(3)：335-342,8.DOI:10.12025/j.issn.1008-6358.2024.20240493
骨/软骨类器官技术变革骨/软骨疾病临床诊疗策略
Bone/cartilage organoid technology transforming clinical diagnosis and treatment strategies
摘要
Abstract
The diagnosis and treatment of motor system diseases are faced with some difficulties,such as unclear mechanism,low diagnostic efficiency,difficult model construction,slow drug development,and hard to bionic repair.Bone/cartilage organoids are a kind of tissue that can simulate the structure and function of bone/cartilage tissue by three-dimensional cultured cells in vitro.It provides a disruptive tool for research on bone/cartilage diseases and greatly revolutionize clinical diagnosis and treatment strategies in orthopedics.This paper systematically introduces the strategies and current research status of constructing bone/cartilage organoids to address the diagnostic and therapeutic dilemmas of bone/cartilage diseases.It proposes cutting-edge advancements that revolutionize clinical diagnosis and treatment strategies while summarizing the three stages of development from basic organoids,structured organoids to functionalized organoids.关键词
骨类器官/软骨类器官/构建策略/发展阶段/临床诊疗Key words
bone organoid/cartilage organoid/construction strategy/development stage/clinical diagnosis and treatment分类
医药卫生引用本文复制引用
李祖浩,陈晓,苏佳灿..骨/软骨类器官技术变革骨/软骨疾病临床诊疗策略[J].中国临床医学,2024,31(3):335-342,8.基金项目
国家自然科学基金重点项目(82230071),国家自然科学基金重大研究计划集成项目(92249303),上海申康医院发展中心"研究型医师创新转化能力培训项目"(SHDC2023CRT013),上海市创新医疗器械应用示范项目(23SHS05700),上海市"科技创新行动计划"(23141900600).Supported by Key Project of National Natural Science Foundation of China(82230071),Major Research Program Integration Project of National Natural Science Foundation of China(92249303),Research Physician Innovation and Transformation Ability Training Program of Shanghai Shenkang Hospital Development Center(SHDC2023CRT013),Shanghai Innovative Medical Device Application Demonstration Project(23SHS05700),and Shanghai Science and Technology Innovation Action Plan(23141900600). （82230071）
