骨/软骨类器官技术变革骨/软骨疾病临床诊疗策略OACSTPCD
Bone/cartilage organoid technology transforming clinical diagnosis and treatment strategies
运动系统疾病诊疗面临机制研究不清、诊断效率低下、模型构建困难、药物研发缓慢、难以仿生修复等难题.骨/软骨类器官是一种新技术,通过体外三维培养细胞构建可模拟骨/软骨结构和功能的组织,为骨/软骨疾病研究提供新工具,变革了骨科临床诊疗策略.本文针对骨/软骨疾病诊疗困境,系统介绍了骨/软骨类器官构建策略及研究现状,提出变革临床诊疗策略的前沿进展,总结骨/软骨类器官从基础类器官、结构化类器官到功能化类器官的3个发展阶段,以期为骨/软骨类器官基础与临床转化研究提供参考.
The diagnosis and treatment of motor system diseases are faced with some difficulties,such as unclear mechanism,low diagnostic efficiency,difficult model construction,slow drug development,and hard to bionic repair.Bone/cartilage organoids are a kind of tissue that can simulate the structure and function of bone/cartilage tissue by three-dimensional cultured cells in vitro.It provides a disruptive tool for research on bone/cartilage diseases and greatly revolutionize clinical diagnosis and treatment strategies in orthopedics.This paper systematically introduces the strategies and current research status of constructing bone/cartilage organoids to address the diagnostic and therapeutic dilemmas of bone/cartilage diseases.It proposes cutting-edge advancements that revolutionize clinical diagnosis and treatment strategies while summarizing the three stages of development from basic organoids,structured organoids to functionalized organoids.
李祖浩;陈晓;苏佳灿
上海交通大学医学院附属新华医院骨科,上海 200092||上海大学转化医学研究院,上海 200444
基础医学
骨类器官软骨类器官构建策略发展阶段临床诊疗
bone organoidcartilage organoidconstruction strategydevelopment stageclinical diagnosis and treatment
《中国临床医学》 2024 (003)
335-342 / 8
国家自然科学基金重点项目(82230071),国家自然科学基金重大研究计划集成项目(92249303),上海申康医院发展中心"研究型医师创新转化能力培训项目"(SHDC2023CRT013),上海市创新医疗器械应用示范项目(23SHS05700),上海市"科技创新行动计划"(23141900600).Supported by Key Project of National Natural Science Foundation of China(82230071),Major Research Program Integration Project of National Natural Science Foundation of China(92249303),Research Physician Innovation and Transformation Ability Training Program of Shanghai Shenkang Hospital Development Center(SHDC2023CRT013),Shanghai Innovative Medical Device Application Demonstration Project(23SHS05700),and Shanghai Science and Technology Innovation Action Plan(23141900600).
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