中国畜牧杂志2024，Vol.60Issue(7)：60-65,6.DOI:10.19556/j.0258-7033.20230807-08
精细胞中促进组蛋白-鱼精蛋白替换的分子机制研究进展
Research Progress on the Molecular Mechanism of Promoting Histone-protamine Replacement in Spermatids
摘要
Abstract
In the process of spermatogenesis,the histone in the chromatin in the round sperm nucleus is gradually replaced by protamine,which makes the chromatin more compact and lays the structural foundation for the specific morphology of the mature sperm head.If the defect of histone-protamine replacement,it will lead to the failure of sperm nuclear condensation,showing abnormal sperm morphology and decreased motility,and difficult fertilization.Studies have shown that a series of changes such as histone post-translational modification,transient DNA strand break,DNA strand break repair and chromatin remodeling complex recognition can promote histone-protamine replacement.This paper reviews the current research progress on the molecular mechanism of promoting histone-protamine replacement from the above aspects,in order to provide a theoretical basis for the diagnosis and treatment of male infertility.关键词
精子形成/组蛋白-鱼精蛋白/表观遗传阅读器/组蛋白翻译后修饰/DNA链断裂/染色质重塑复合体Key words
Spermatogenesis/Histone-protamine/Epigenetic reader/Histone post-translational modification/DNA strand break/Chromatin remodeling complex分类
畜牧业引用本文复制引用
姚顺发,许庆龙,张君正,曹立朋,陈璇,金一..精细胞中促进组蛋白-鱼精蛋白替换的分子机制研究进展[J].中国畜牧杂志,2024,60(7):60-65,6.基金项目
国家自然科学基金(31960659) （31960659）
