中医康复2024，Vol.1Issue(6)：35-39,5.DOI:10.19787/j.issn.2097-3128.2024.06.008
不同干燥方法下厚朴温中汤物质基准关键质量属性的差异
Differences in Key Quality Attributes of Substance Benchmark of Houpu Wenzhong Tang Decoction by Different Drying Methods
摘要
Abstract
Objective:Comparative study on the key quality attributes(fingerprint,index component content,and dry powder properties)of Houpu Wenzhong Tang decoction by different drying methods,optimizing the drying process,and providing a reliable basis for the preparation process of Houpu Wenzhong granules.Methods:UPLC was used to determine the fingerprint of dry powder by different drying methods,and the content of in-dex components(Magnolol,Honokiol,Hesperidin)of different dry powder was determined by HPLC.The UPLC fingerprint similarity,index compo-nent content,and dry powder properties of substance benchmark of Houpo WenZhong decoction prepared by vacuum drying,spray drying,and freeze drying were analyzed to optimize drying methods.Results:By comparing the key quality attributes of the substance benchmark by the three drying methods,it was found that the similarity of UPLC fingerprint was more than 0.9,the index components content of substance benchmark by spray drying and freeze drying was higher than that by vacuum drying,and the dry powder obtained by freeze drying was loose and porous,with poor fluidity and good re-solubility.The dry powder obtained by vacuum drying and spray drying had good fluidity and slow re dissolution rate.Con-clusion:The chemical composition of the dry powder obtained by freeze-drying and spray drying is highly similar to that of the decoction,and the re-tention rate of the index composition is high.The former has good powder re-solubility,which is suitable for preparing the substance benchmark of Houpu Wenzhong Decoction.The latter has good powder liquidity,which is conducive to the formation of the preparation,and is suitable for the in-dustrial production of Houpu Wenzhong Granules.关键词
厚朴温中汤/干燥方法/UPLC指纹图/指标成分Key words
Houpu Wenzhong Tang/Drying methods/UPLC fingerprint/index component分类
医药卫生引用本文复制引用
冯健英,陈雪婷,徐文杰,张建军..不同干燥方法下厚朴温中汤物质基准关键质量属性的差异[J].中医康复,2024,1(6):35-39,5.基金项目
广东省中医药局科研项目(20211040) （20211040）
