进展期腺瘤性大肠息肉不同中医证候患者肠道菌群特点的临床研究OACSTPCD

Objective To analyze the characteristics of intestinal flora in patients with advanced adenomatous colorectal polyps with different Traditional Chinese Medicine(TCM)syndromes.Methods This case-control study enrolled patients with adenomatous colorectal polyps treated at Shenzhen Hospital(Longgang)of Beijing University of Chinese Medicine from December 2020 to March 2023.The TCM syndrome types of patients were identified,and their stool samples were collected for intestinal flora analysis.Results A total of 214 patients participated in the study,including 107 with advanced adenomas and 107 common adenomas.Compared with the common adenoma group,the number of intestinal Escherichia coli and Staphylococcus in the advanced adenoma group was significantly increased,while the number of lactobacillus and Bifidobacterium was significantly decreased(P<0.05).Escherichia coli,Staphylococcus,Lactobacillus and Bifidobacterium were all independent risk factors for the transition from common adenoma to advanced adenoma(P<0.05).Compared with common adenoma group,the number of intestinal Escherichia coli and staphylococcus was significantly increased in intestinal damp-heat syndrome group,spleen deficiency with stasis syndrome group,dampness-stasis syndrome group and Qi stagnation and blood stasis syndrome group,while the number of lactobacillus and bifidobacterium was significantly decreased(P<0.05).Compared with Qi stagnation and blood stasis syndrome group,the number of intestinal Escherichia coli and staphylococcus in intestinal damp-heat syndrome group,spleen deficiency with stasis syndrome group and dampness-stasis syndrome group was significantly increased,while the number of lactobacillus and Bifidobacterium was significantly decreased(P<0.05).Compared with the dampness-stasis syndrome group,the number of Escherichia coli and Staphylococcus in intestinal damp-heat syndrome group was significantly increased,while the number of lactobacillus and Bifidobacterium was significantly decreased.The number of Lactobacillus in spleen-deficiency syndrome group was significantly decreased(P<0.05).Compared with spleen deficiency and stasis syndrome group,the number of Escherichia coli and Staphylococcus in intestinal damp-heat syndrome group was significantly increased,while the number of Lactobacillus and Bifidobacterium was significantly decreased(P<0.05).Conclusion Significant increases in Escherichia coli and Staphylococcus counts and decreases in Lactobacillus and Bifidobacterium counts are risk factors for the progression from common adenomas to advanced adenomas.The imbalance of intestinal flora occurs in patients with advanced adenomas across different TCM syndromes,with notable differences between groups.