基于静息态功能磁共振成像观察电针治疗AIS患者的即刻脑网络变化OA北大核心CSTPCD

Objective: To investigate the changes of immediate sensory motor network (SMN) and default mode network (DMN) in patients with acute ischemic stroke (AIS) using resting-state functional magnetic resonance imaging (rs-fMRI) and independent component analysis (ICA). Materials and Methods: Twenty-seven patients with AIS and 27 healthy controls (HCs) were included in the study. Each subject was assessed on relevant clinical scales and baseline data were collected, followed by immediate electroacupuncture stimulation for AIS, and relevant rs-fMRI data were collected. Then, the SMN and DMN network components were extracted using the ICA method. The functional connectivity values of patients and healthy controls were compared, as well as the changes in functional connectivity before and after acupuncture; bias correlation analysis was performed between the change values and the corresponding changes in clinical scale scores; and then the differential brain regions were used as seed points to calculate their functional connectivity (FC) with the whole brain. Results: Before acupuncture, functional connectivity increased in the left prefrontal lobe of the AIS group comparable to the healthy control group (P<0.001), and decreased in the left subparietal lobule (Z=4.38, P<0.001) and the right posterior cingulate gyrus (Z=4.87, P<0.001); the FC values of the left subparietal lobule (P<0.001), the left posterior cingulate gyrus (P<0.001), and the left frontal lobe (P<0.001) increased, increased FC values in some cerebellar regions (P<0.001). After acupuncture, the functional connectivity of the right prefrontal lobe in the AIS group significantly increased (P<0.001) and strongly and positively correlated with the difference of (Fugl-Meyer Assessment, FMA) score (r=0.842, P<0.001); the FC values of the right thalamus (Z=4.38, P<0.001) and the left frontal lobe in the AIS group significantly increased (P<0.001), and the FC values of some cerebellar regions increased. Conclusions: AIS patients have abnormal brain activity in the limbic system (posterior cingulate gyrus, hippocampus)-thalamus-cortex (subparietal lobule-frontal lobe) neural circuit; electroacupuncture can immediately modulate the brain spontaneous activity of AIS patients, which involves the brain areas related to motor completion, and it may be a potential target brain area for electroacupuncture treatment of AIS.