摘要
Abstract
Objective To explore potential causal relationships between physical activity of varying intensity and serum uric acid levels.Methods A genome-wide association study between physical activity of different intensities and serum uric acid levels was used for the Mendelian randomization study.Inverse-variance weighted(IVW)analysis method was used as the primary analysis method.Sensitivity analyses were used to test the reliability of the MR analysis results.Results Among the results of the IVW method,low-intensity aero-bic training,light physical activity,and moderate-intensity physical activity had a significant causal effect on the reduction of serum uric acid levels(OR=0.69,95％CI:0.50～0.96,p=0.031);(OR=0.60,95％CI:0.45～0.80,p=0.000 6);(OR=0.85,95％CI:0.75～0.96,p=0.01),but strenuous physical activity had no significant effect on serum uric acid levels(OR=0.92,95％CI:0.77～1.10,p=0.39).Sensitivity analyses showed no evidence of reverse causality,pleiotropy or heterogeneity.Conclusion Low-intensity aerobic training,light physical activity,and moderate-intensity physical activity provided genetic evidence of a causal association for the reduction in serum uric acid levels,whereas there was no direct causal association between vigorous physical activity and the reduction in serum uric acid levels.关键词
身体活动/血清尿酸水平/孟德尔随机化/因果关联Key words
physical activity/serum uric acid level/mendelian randomization/causal association分类
社会科学
