家畜生态学报2024，Vol.45Issue(7)：21-27,7.DOI:10.3969/j.issn.1673-1182.2024.07.004
玉米烯酮与氟苯尼考对雏鸡免疫功能和生长性能的影响
The Effect of Zearalenone and Florfenicol on Immune Function and Growth Performance of Chicks
摘要
Abstract
Zearalenone(ZEN)is a common environmental pollutant,while florfenicol(FFC)is a very widely used antimicrobial drug in veterinary clinic.They are highly likely to be exposed at the same time and have toxic and side effects on animals,but no relevant studies have been reported.To investigate the effects of single and combined exposure to ZEN and FFC on growth performance and immune function of chicks,forty 1-day-old chicks were adaptively fed for 2 days,then they were randomly divided into 4 groups with 10 chicks(half male and half female)in each group.The chicks in Control group were fed with a basal diet,and those in ZEN group were poisoned by gavage with dose of 1 mg·kg-1 diet for 21 days,those in FFC group were treated by water administration with 100 mg·L-1 drinking water for the first 5 days,while those in ZEN+FFC group were poisoned by gavage with dose of 1 mg·kg-1 diet for 21 days and treated by water administration with 100 mg·L-1 drinking water for the first 5 days.The experiment lasted 21 days.The average daily gain,organ index and feed to gain ratio of chicks were measured.Serum levels of cytokines and Newcastle disease antibody were detected by ELISA kit.The results showed that al-though ZEN was at low pollution level,it could inhibit the secretion of IL-2 and IFN-γ,thereby inhibiting immune function of chicks,and might induce inflammatory response by promoting the release of IL-1,IL-6 and TNF-α.Early treatment of FFC could not only inhibit the growth of chicks,but also down-regulate the secretion of IL-2 and IFN-γ,resulting in immunosuppression.The combined exposure to ZEN and FFC mitigated their inhibition to IL-2 and IFN-γ and controlled inflammatory responses induced by ZEN,how-ever,it also inhibited the humoral immune response of chicks.Therefore,the monitoring of ZEN contami-nation in the feed of chicks should be enhanced.FFC should be cautiously used for health protection drug-sin chicks since they were born.In addition,vaccination should be avoided when chicks were exposed to both ZEN and FFC in order to prevent the failure of immunization.关键词
玉米烯酮/氟苯尼考/鸡/细胞因子/生长性能Key words
zearalenone/florfenicol/chicks/cytokine/growth performance分类
畜牧业引用本文复制引用
杨昱暄,王廷梅,吕世明,王忠,刘宝生,王旺,胡梦鑫,王立琦..玉米烯酮与氟苯尼考对雏鸡免疫功能和生长性能的影响[J].家畜生态学报,2024,45(7):21-27,7.基金项目
国家自然科学基金资助项目(32160853,32260829) （32160853,32260829）
贵州大学自然科学专项(特岗)科研基金项目((2022)21号) （特岗）
贵州省自然科学基金项目(黔科合基础[2022]一般113) （黔科合基础[2022]一般113）
贵州省地方鸡育繁推一体化示范基地(黔教技[2022]061) （黔教技[2022]061）
贵州省科技计划项目(黔科合支撑[2022]重点34) （黔科合支撑[2022]重点34）
江西省自然科学基金重点项目(20202ACBL205009) （20202ACBL205009）
