吉林中医药2024，Vol.44Issue(7)：749-753,5.DOI:10.13463/j.cnki.jlzyy.2024.07.002
基于"络以通为用"探讨马钱子在特发性肺纤维化治疗中的应用
On the application of nux vomica in the treatment of idiopathic pulmonary fibrosis based on the theory of"collaterals functioning normally when unblocked"
摘要
Abstract
Idiopathic pulmonary fibrosis belongs to the categories of"lung bi"and"lung flaccidity"in traditional Chinese medicine,whose core pathogenesis features chronic phlegm and blood stasis blocking lung collaterals,leading to lung collaterals blockage.Ye Tianshi proposed a theory that"collaterals only function normally when unblocked",under which the application of drugs for removing obstruction in collaterals during the acute phase of idiopathic pulmonary fibrosis can dredge the pulmonary collaterals and alleviate acute attacks.Nux vomica turns out to be effective in eliminating the pathogens of phlegm and blood stasis accumulated in the lung collaterals.Li Guangxi found in clinic that although the herb has toxicity,it can dredge collaterals powerfully and rapidly,and is often used to treat the syndrome of phlegm and blood stasis obstructing collaterals.Accordingly,applying nux vomica in a safe dose to treat acute attacks of idiopathic pulmonary fibrosis can significantly improve the clinical symptoms of patients and reduce the frequency of attacks.In this paper,the pathogenesis of acute onset of idiopathic pulmonary fibrosis is discussed,and the mechanism of action of nux vomica on acute onset of idiopathic pulmonary fibrosis is discussed from the perspective of traditional Chinese medicine and western medicine,as well as the precautions for its clinical application,in order to provide new ideas for the clinical treatment of idiopathic pulmonary fibrosis.关键词
特发性肺纤维化/肺痹/肺络/络以通为用/马钱子Key words
idiopathic pulmonary fibrosis/lung bi/lung collaterals/collaterals functioning normally when unblocked/nux vomica分类
医药卫生引用本文复制引用
刘晓红,李光熙..基于"络以通为用"探讨马钱子在特发性肺纤维化治疗中的应用[J].吉林中医药,2024,44(7):749-753,5.基金项目
国家自然科学基金项目(82074262) （82074262）
