国际眼科杂志2024，Vol.24Issue(8)：1260-1265,6.DOI:10.3980/j.issn.1672-5123.2024.8.15
VEGF在糖尿病视网膜病变破坏血-视网膜屏障机制中的研究新进展
Research progress of vascular endothelial growth factor in the mechanism of blood-retinal barrier damage by diabetic retinopathy
摘要
Abstract
Diabetic retinopathy(DR)is one of the common causes of visual impairment and blindness in adults,which is caused by various pathogenesis.Although the mechanism of DR has not been elucidated yet,the destruction of blood-retinal barrier is a key process.As a highly endothelial-specific factor in promoting the growth of vascular endothelial cell,vascular endothelial growth factor(VEGF)plays a crucial role in the formation of pathological retinal neovascularization and the destruction of blood-retinal barrier.Therefore,a comprehensive understanding of the etiology and pathogenesis of blood-retinal barrier damage promoted by VEGF is critical for exploring the pathogenesis of DR.In this study,the underlying relationship between VEGF and the mechanism of blood-retinal barrier damage,including retinal vascular endothelial cell permeability,vascular inflammatory response,apoptosis,oxidative stress,mitochondrial damage and endoplasmic reticulum stress,with a view to providing a reference for the study in VEGF in the pathogenesis of blood-retinal barrier damage in DR.关键词
糖尿病视网膜病变/血-视网膜屏障/血管内皮生长因子(VEGF)Key words
diabetic retinopathy/blood-retinal barrier/vascular endothelial growth factor(VEGF)引用本文复制引用
王苏涵,张乐颖,秦婷婷,王娇娇,宋宗明..VEGF在糖尿病视网膜病变破坏血-视网膜屏障机制中的研究新进展[J].国际眼科杂志,2024,24(8):1260-1265,6.基金项目
河南省科技攻关联合共建项目(No.LHGJ20190817) （No.LHGJ20190817）
中原科技领军人才项目(No.224200510013) （No.224200510013）
河南省立眼科医院基础研究专项(No.20JCZD001) Joint Project of Medical Science and Technology of Henan Province(No.LHGJ20190817) （No.20JCZD001）
Central Plains Science and Technology Leading Talents(No.224200510013) （No.224200510013）
Basic Research Project of Henan Eye Hospital(No.20JCZD001) （No.20JCZD001）
