器官移植2024，Vol.15Issue(4)：558-562,5.DOI:10.3969/j.issn.1674-7445.2024087
肾移植受者免疫抑制方案的优化
Optimization of immunosuppressive regimen for kidney transplant recipients
摘要
Abstract
With the maturity and development of surgical techniques,as well as the improvement of perioperative management level,the success rate of kidney transplantation has been significantly improved.However,due to evident differences in heredity and antigenicity between donors and recipients,rejection will occur after kidney transplantation,which will affect the survival of renal grafts.Immunosuppression is an important treatment for rejection,which is of significance to reduce the risk of rejection and enhance graft survival rate.Nevertheless,immunosuppressants may cause multiple complications while lowering the incidence of rejection,such as infection,cardiovascular diseases and tumors,etc.,which seriously affect the quality of life of patients and may even lead to their death.Reasonable selection of immunosuppressants and continuous optimization of immunosuppressive regimen for recipients play a critical role in improving the survival of recipients and renal grafts.In this article,the development history of organ transplantation,immune induction therapy and immune maintenance therapy was reviewed,and the progress in the optimization of immunosuppressive regimens for kidney transplant recipients was discussed,aiming to provide reference for improving clinical prognosis of kidney transplant recipients.关键词
肾移植/免疫抑制药/免疫诱导/免疫维持/感染/糖皮质激素/钙调磷酸酶抑制剂/抗增殖类药物Key words
Kidney transplantation/Immunosuppressant/Immune induction/Immune maintenance/Infection/Glucocorticoid/Calcineurin inhibitor/Antiproliferative drug分类
医药卫生引用本文复制引用
董震,王洪阳..肾移植受者免疫抑制方案的优化[J].器官移植,2024,15(4):558-562,5.基金项目
山东省自然科学基金青年项目(ZR2020QH237) （ZR2020QH237）
青岛大学附属医院青年科学基金(QDFYQN2023120) （QDFYQN2023120）
