四川医学2024，Vol.45Issue(6)：582-586,5.DOI:10.16252/j.cnki.issn1004-0501-2024.06.002
血清HNL、PCT、sCD163及IL-6联合检测在老年患者脓毒症诊断中的应用价值
Application Value of Serum HNL,PCT,sCD163 and IL-6 Combined Detection in Diagnosis of Sepsis in Elderly Patients
摘要
Abstract
Objective To comprehensively evaluate the application of human neutrophil lipocalin(HNL)combined with other biomarkers in the early diagnosis of sepsis in elderly patients.Methods From May 2019 to November 2022,115 elderly pa-tients treated in our hospital were selected.According to the"sepsis 3"consensus criteria,clinical history and laboratory examina-tion,they were divided into:sepsis group(n=35),acute local bacterial infection group(n=50),viral infection group(n=30)and healthy control group(n=50).Intravenous blood samples were collected from patients after diagnosis and analyzed for CBC,blood culture,microbial culture,HNL,procalcitonin(PCT),interleukin-6(IL-6),and soluble hemoglobin scavenger receptor(sCD163)levels.Results In the diagnosis of sepsis in elderly patients,the sensitivity and specificity of combined detection of HNL and PCT were 91.4％ and 98％,respectively,which were significantly better than those of using 1.025 ng/ml as the best cut-off value of PCT and 98.91 ng/ml as the best cut-off value of HNL(84％).In the diagnosis of local bacterial infection in elderly patients,the sensitivity and specificity of combined detection of HNL and PCT were 88％ and 90％,which were significantly better than those of PCT and HNL alone.Conclusion HNL combined with PCT is helpful for early diagnosis of sepsis and local bacterial infection in elderly patients.关键词
老年脓毒症/人中性粒细胞载脂蛋白/降钙素原Key words
senile sepsis/human neutrophilic apolipoprotein/procalcitonin分类
医药卫生引用本文复制引用
赵刚,单思阳,何月月,赵星,郭凡..血清HNL、PCT、sCD163及IL-6联合检测在老年患者脓毒症诊断中的应用价值[J].四川医学,2024,45(6):582-586,5.基金项目
新疆维吾尔自治区自然科学基金面上项目(编号:2021D01C402) （编号:2021D01C402）
新疆维吾尔自治区自然科学基金青年科学基金(编号:2022D01C807) （编号:2022D01C807）
新疆医科大学大学生创新训练计划项目(编号:s202010760042) （编号:s202010760042）
