摘要
Abstract
Objective To investigate the clinical significance of serum follistatin-like protein 1(FSTL1)and interleu-kin-11(IL-11)expression in elderly patients with chronic heart failure(CHF)and its influence on prognosis.Methods 137 elderly patients with CHF in our hospital from June 2019 to June 2022 were prospectively selected as the research subjects.Baseline data of patients were recorded at admission,the indexes of cardiac function[left ventricular end diastolic diameter(LVEDd),left ventricular ejection fraction(LVEF)],serum FSTL1,blood inflammatory indexes(IL-11,IL-1β)and myocardial injury markers[cardiac troponin I(cTnI),N-terminal pro-B-type natriuretic peptide(NT-pro BNP)]levels of patients were measured and recorded,treatment was performed.After 6 months of follow-up,the prognosis of patients was observed,the prognosis was evaluated according to the major adverse cardiac events(MACE)within 6 months of follow-up.Baseline data,cardiac function related indexes and serum indexes of patients with different prognosis were compared,the clinical significance of serum FSTL1 and IL-11 expression in elderly patients with CHF and its influence on prognosis were mainly analyzed.Results After the statistics of 6-month follow-up after the end of treat-ment,of 137 elderly patients with CHF in this study,22 developed MACE,of which 15 cases had malignant arrhythmia,7 cases had heart failure,the poor prognosis of patients accounted for 16.06%.Univariate analysis showed that LVEF and FSTL1 in the poor prog-nosis group were lower than those in the good prognosis group,while LVEDd,neutrophil/lymphocyte ratio(NLR),IL-11,IL-1β,cTnI and NT-Pro BNP were higher than those in the good prognosis group(P<0.05).Through multivariate Logistic regression analysis,the results showed that serum FSTL1 and IL-11 were independent prognostic factors for elderly CHF patients(P<0.05).The ROC curve was drawn,and the results showed that the AUC of serum FSTL1 and IL-11 at admission alone and in combination in predicting the poor prognosis in elderly patients with CHF were 0.858,0.861 and 0.874,respectively,which had certain predictive value.Spearman correlation analysis test showed that serum FSTL1 and IL-11 levels were negatively correlated in elderly patients with CHF(r=-0.217,P=0.011).Conclusion High expression of serum FSTL1 can reduce the risk of poor prognosis in elderly patients with CHF,high expression of IL-11 increases the risk of poor prognosis in elderly patients with CHF,serum FSTL1 and IL-11 at admission can be used to predict the poor prognosis of elderly patients with CHF.关键词
慢性心力衰竭/卵泡抑素样蛋白1/白细胞介素-11Key words
chronic heart failure/follistatin-like protein 1/interleukin-11分类
医药卫生
