四川医学2024，Vol.45Issue(7)：697-702,6.DOI:10.16252/j.cnki.issn1004-0501-2024.07.001
绝经后妇女血浆致动脉粥样硬化指数与心血管病风险的关系及其对高危心血管病的预测价值
The Relationship Between Atherogenic Index of Plasma and Cardiovascular Disease Risk in Postmenopausal Women and its Predictive Value for Cardiovascular Disease of High Risk
摘要
Abstract
Objective To explore the relationship between atherogenic index of plasma(AIP)and 10-year cardiovascular disease(CVD)risk assessed by the Framingham Risk Score(FRS)in postmenopausal women,and to evaluate predictive value of AIP for high-risk CVD in postmenopausal women.Methods Total 462 postmenopausal women(postmenopausal women group)and 196 premenopausal women(premenopausal women group)undergoing physical examination were selected.AIP was calculated in logarithmic form[triglyceride(TG)/high-density lipoprotein cholesterol(HDL-C)].FRS was used to assess CVD risk,and postm-enopausal women were divided into low-risk CVD group(307 cases)and high-risk group(155 cases)based on FRS scores.Analyze relationship between AIP and variables as well as FRS,influencing factors of high-risk CVD in postmenopausal women.The predic-tive value of AIP for high-risk CVD in postmenopausal women was analyzed using receiver operating characteristic(ROC)curves.Results Compared with premenopausal women,postmenopausal women had significantly higher age,BMI,systolic blood pressure,diastolic blood pressure,TG,total cholesterol,low-density lipoprotein cholesterol(LDL-C),HDL-C,fasting blood glucose,AIP,and FRS(all P＜0.05).Meanwhile,proportions of smoking,hypertension,diabetes,and high-risk FRS were significantly increased in postmenopausal women(all P＜0.05).Pearson correlation analysis showed that AIP was positively correlated with age,BMI,systol-ic blood pressure,diastolic blood pressure,LDL-C,and FRS.Further multiple linear regression analysis found that AIP was inde-pendently correlated with FRS in postmenopausal women(β=0.433,P＜0.001).Multivariate Logistic regression analysis sugges-ted that AIP remained an independent risk factor for high-risk CVD in postmenopausal women after adjusting for confounding factors(OR 7.301,95％CI 2.469～15.668,P＜0.001).ROC curve analysis showed that the area under the curve for AIP predicting high-risk CVD in postmenopausal women was 0.868(95％CI 0.836～0.900),with an optimal cutoff value of-0.035,sensitivity of 88.47％,and specificity of 81.23％.Conclusion AIP of postmenopausal women would be significantly higher than that before men-opause and would be closely related to CVD risk.AIP could be used to effectively predict high-risk CVD in postmenopausal women.关键词
弗明翰风险评分/血浆致动脉粥样硬化指数/心血管病风险/高危/绝经后妇女Key words
Framingham risk score/atherogenic index of plasma/risks of cardiovascular disease/high risk/postmenopa-usal women分类
医药卫生引用本文复制引用
何津锐,杨雁华,曾一,黄燕,马孝湘..绝经后妇女血浆致动脉粥样硬化指数与心血管病风险的关系及其对高危心血管病的预测价值[J].四川医学,2024,45(7):697-702,6.基金项目
四川省干部保健科研课题(编号:2023-219) （编号:2023-219）
2024电子科技大学大学生创新创业训练计划项目(编号:2024106141015) （编号:2024106141015）
