点刺放血配合中药治疗儿童急性化脓性扁桃体炎的疗效观察OACSTPCD
Therapeutic observation of bloodletting plus Chinese medication in treating acute suppurative tonsillitis in children
目的 观察少商和商阳穴点刺放血配合蓝芩口服液治疗儿童急性化脓性扁桃体炎的临床疗效.方法 将 72 例急性化脓性扁桃体炎患者随机分为对照组(40 例)和研究组(32 例).对照组采用口服蓝芩口服液治疗,研究组采用少商、商阳点刺放血配合蓝芩口服液治疗.记录两组患者退热时间、扁桃体红肿消退时间、咽痛消失时间,观察两组治疗前后各项症状和体征积分及各项实验室指标[外周血白细胞计数(white blood cell,WBC)、中性粒细胞计数(neutrophilic granulocyte,GRA)、肿瘤坏死因子-α(tumor necrosis factor-α,TNF-α)、C反应蛋白(C-reactive protein,CRP)、白细胞介素-2(interleukin-2,IL-2)、白细胞介素-17(interleukin-17,IL-17)]及T淋巴细胞各项指标(CD3﹢、CD4﹢、CD8﹢、CD4﹢/CD8﹢)的变化情况.结果 研究组总有效率为 93.8%,明显高于对照组的 75.0%(P<0.05).两组治疗后各项症状和体征积分、CD8﹢及WBC、GRA、TNF-α、CRP、IL-17水平均较同组治疗前显著下降,CD3﹢、CD4﹢、CD4﹢/CD8﹢及 IL-2 水平均显著上升,差异均具有统计学意义(P<0.05).研究组治疗后退热时间、扁桃体红肿消退时间、咽痛消失时间均明显短于对照组,各项症状和体征积分、CD8﹢及WBC、GRA、TNF-α、CRP、IL-17水平均明显低于对照组,CD3﹢、CD4﹢、CD4﹢/CD8﹢及IL-2 水平均明显高于对照组,差异均有统计学意义(P<0.05).结论 少商、商阳点刺放血配合蓝芩口服液治疗儿童急性化脓性扁桃体炎疗效确切,可通过调节细胞免疫减轻患者机体炎症水平,加速症状体征缓解.
Objective To observe the clinical efficacy of bloodletting at Shaoshang(LU11)and Shangyang(LI1)plus Lan Qin oral liquid in treating acute suppurative tonsillitis in children.Method Seventy-two patients with acute suppurative tonsillitis were randomized into a control group of 40 cases and a research group of 32 cases.The control group was treated with oral administration of Lan Qin oral liquid,and the research group was given bloodletting at Shaoshang and Shangyang points plus Lan Qin oral liquid.The defervescence time,time for tonsil redness and swelling to subside,and relief time of the sore throat were recorded.The following indexes were observed before and after the treatment in both groups:symptom and sign scores,laboratory indexes[peripheral blood white blood cell(WBC)and neutrophilic granulocyte(GRA)counts,tumor necrosis factor-α(TNF-α),C-reactive protein(CRP),interleukin-2(IL-2),interleukin-17(IL-17)],and T-lymphocyte indicators(CD3﹢,CD4﹢,CD8﹢,and CD4﹢/CD8﹢).Result The total effective rate was 93.8% in the research group,significantly higher than 75.0% in the control group(P<0.05).In both groups,the symptom and sign scores and the levels of CD8﹢,WBC,GRA,TNF-α,CRP,and IL-17 dropped significantly,and the levels of CD3﹢,CD4﹢,CD4﹢/CD8﹢,and IL-2 increased significantly(P<0.05).The research group took a shorter time to subside the fever,tonsil redness and swelling,and sore throat than the control group;the symptom and sign scores and the levels of CD8﹢,WBC,GRA,TNF-α,CRP,and IL-17 were lower and the levels of CD3﹢,CD4﹢,CD4﹢/CD8﹢,and IL-2 were higher in the research group than in the control group after the treatment,all showing statistical significance(P<0.05).Conclusion Bloodletting at Shaoshang(LU11)and Shangyang(LI1)plus Lan Qin oral liquid is effective for acute suppurative tonsillitis in children.This method can reduce the inflammatory level by regulating cellular immunity,thus accelerating the relief of symptoms and signs.
冯海荣;喜雷;郭凯;赵禧;李媛媛
北京市通州区妇幼保健院,北京 101100中国中医科学院望京医院,北京 100102中国人民解放军总医院第八医学中心,北京 100091
中医学
针刺疗法化脓性扁桃体炎蓝芩口服液刺血疗法细胞免疫穴,少商穴,商阳
Acupuncture therapySuppurative tonsillitisLan Qin oral liquidBloodletting therapyCellular immunityPoint,Shaoshang(LU11)Point,Shangyang(LI1)
《上海针灸杂志》 2024 (007)
719-724 / 6
北京市通州区科技计划项目(KJ2020CX015);北京市中医药科技发展资金项目青年规划项目(QN-2020-10)
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