食品工业科技2024，Vol.45Issue(15)：25-33,9.DOI:10.13386/j.issn1002-0306.2023100198
酵母抽提物与姜黄素复合对急性酒精性肝损伤小鼠肠道菌群的调节作用
Regulation of Yeast Extract-Curcumin on Intestinal Flora in Mice with Acute Alcoholic Liver Injury
摘要
Abstract
Objective:This study aimed to investigate the protective effect and mechanism of yeast extract and curcumin-yeast extract on acute alcoholic liver injury in mice.Methods:The mouse model of acute alcoholic liver injury was established,and the mice were administered with yeast extract and curcumin-yeast extract.Changes in ALT,AST,T-GSH,GSH-Px,and MDA levels were observed in the serum and liver tissue,respectively.Pathological sections of liver tissue were examined to observe the damage.The intestinal flora of mice was analyzed.Results:Compared with the model group,both yeast extract and curcumin-yeast extract reduced the levels of ALT,AST,MDA,TC,and TG,increased the activities of GSH-Px and T-GSH,and alleviated fatty infiltration and inflammatory infiltration of hepatocytes.Curcumin-yeast extract effectively restored the abundance of Acinetobacter,Prevotella,and Ruminococcus,which had been altered by alcohol.The restorative effect was superior to that of the yeast extract group.Conclusion:Yeast extract and curcumin-yeast extract showed significant protective effects against acute alcoholic liver injury in mice.This mechanism may be associated with the regulation of oxidative stress,lipid metabolism,and intestinal flora.关键词
酵母抽提物/姜黄素/急性酒精性肝损伤/肠道菌群Key words
yeast extract/curcumin/acute alcoholic liver injury/intestinal flora分类
轻工纺织引用本文复制引用
黄晓英,余海立,郑明山,刘晓雯,张彦..酵母抽提物与姜黄素复合对急性酒精性肝损伤小鼠肠道菌群的调节作用[J].食品工业科技,2024,45(15):25-33,9.基金项目
国家重点研发计划资助(2022YFF1103300) （2022YFF1103300）
湖北省老年胃肠癌精准防治临床医学中心开放基金(2022EGC-06). （2022EGC-06）
