食品工业科技2024，Vol.45Issue(15)：152-160,9.DOI:10.13386/j.issn1002-0306.2024020076
负载花色苷的抗酸性羧甲基壳聚糖凝胶微球的缓释研究
Sustained Release Properties of Acid Resistant Carboxymethyl Chitosan Gel Microspheres Loaded with Anthocyanins
摘要
Abstract
This study was aimed at broadening the application range of chitosan hydrogels and constructing an edible anthocyanins(ACNs)delivery system.The acid resistant carboxymethyl chitosan(CMCS)gel microspheres(ACNs/CMCS-SA)loaded with ACNs were prepared by inversion-phase emulsion method.During the process,corn oil was used as continuous phase and salicylaldehyde(SA)was used as crosslinking agent.The structure and morphology of ACNs/CMCS-SA were characterized.And the stability,swelling ability and sustained release properties were studied.The results showed that ACNs/CMCS-SA had a micron particle size with smooth and round surface.The gel microspheres showed good acid resistance and pH responsiveness during swelling and sustained release experiments.The sustained release behavior of ACNs conformed to Weibull model.In pH7 and pH9 media,the release process of ACNs was controlled by a combination mechanism of diffusion and skeleton dissolution.In pH3 and 5 media,it was controlled by a combination ofFick diffusion and Case Ⅱ transport(order 0 grade-swelling dependent release).The preparation method of ACNs/CMCS-SA was simple and green,and the sample exhibited good gastric acid protection and intestinal release performance for ACNs.Therefore,this study lays a theoretical and experimental foundation for the development of environmentally friendly drug encapsulation materials and the application of ACNs.关键词
花色苷(ACNs)/释放性能/动力学/pH响应/反相乳液法/凝胶微球Key words
anthocyanins(ACNs)/release properties/dynamics/pH response/inversion-phase emulsion method/gel microsphere分类
轻工纺织引用本文复制引用
李煦,储若晴,刘欣茹,刘长霞,叶霞,范小振..负载花色苷的抗酸性羧甲基壳聚糖凝胶微球的缓释研究[J].食品工业科技,2024,45(15):152-160,9.基金项目
河北省高等学校科学研究项目(ZC2022044) （ZC2022044）
沧州师范学院2023年度大学生科技创新能力培育专项(DXSZDL2023002) （DXSZDL2023002）
沧州师范学院科研创新团队资助(cxtd11901). （cxtd11901）
