食品工业科技2024，Vol.45Issue(15)：452-460,9.DOI:10.13386/j.issn1002-0306.2023100148
膳食纤维缓解结肠炎作用机制研究进展
Advances in Understanding the Role Mechanism of Dietary Fiber in Mitigating Colitis
摘要
Abstract
Colitis is an inflammatory intestinal disease that lasts for a long time,has an unknown cause,and occurs repeatedly.It is usually accompanied by symptoms such as intestinal cell damage,intestinal immunity,and abnormal intestinal flora.Numerous studies have shown that dietary fiber,as a prebiotic,its metabolites can selectively improve the composition of the intestinal flora,which in turn improves the level of intestinal short-chain fatty acids,reduces the expression of inflammatory factors,and enhances the function of the intestinal immune barrier,thereby improving the inflammatory response of the organism.This anti-inflammatory effect of dietary fiber through its metabolites provides new research ideas to assist in the treatment of colitis.This paper outlines the pathogenesis of colitis,and the mechanism of interaction between dietary fiber and its metabolites with intestinal flora,inflammatory factors and immune cells,aiming to provide theoretical basis for the alleviation of colitis by dietary fiber and the development of functional foods.关键词
膳食纤维/结肠炎/肠道菌群/免疫屏障/作用机制Key words
dietary fiber/colitis/intestinal microbiota/immune barrier/mechanism of action分类
轻工纺织引用本文复制引用
王勇,李玥,崔丽娴,刘素稳,何大柃,常学东..膳食纤维缓解结肠炎作用机制研究进展[J].食品工业科技,2024,45(15):452-460,9.基金项目
国家重点研发计划(2023YFD1600803) （2023YFD1600803）
河北省产业创新创业团队(215A7103D) （215A7103D）
河北省重点研发计划(23317102D). （23317102D）
