食品科学2024，Vol.45Issue(13)：146-152,7.DOI:10.7506/spkx1002-6630-20231020-156
4株双歧杆菌对秀丽隐杆线虫的体内抗衰老作用
Anti-aging Effects of Four Bifidobacterium Species on Caenorhabditis elegans
摘要
Abstract
The anti-aging effects of four Bifidobacterium species(B.pseudospermum BP-1,B.longum BL-3,B.animalis BA-5 and B.infantis BI-38)on Caenorhabditis elegans were evaluated in terms of its lifespan,reproductive capacity,vitality,body shape,stress resistance,lipofuscin levels,antioxidant enzyme activity and malondialdehyde(MDA)content.The results showed that compared with the control group(Escherichia coli OP50),BA-5 and BI-38 effectively extended the lifespan of C.elegans(P＜0.05),while BP-1 and BL-3 had no significant effect on the lifespan of C.elegans(P＞0.05).Meanwhile,BA-5 and BI-38 did not impair the reproductive or locomotory capacities of C.elegans(P＞0.05),but could effectively enhance its pharyngeal pumping and reduce its body size(P＜0.05).BA-5 and BI-38 were able to enhance tolerance to heat or oxidative stress and thus prolong the lifespan of C.elegans(P＜0.05),significantly reduce lipofuscin accumulation and MDA content(P＜0.05),and significantly increase the activity of two antioxidant enzymes(catalase and superoxide dismutase)in C.elegans(P＜0.05).In conclusion,B.infantis BI-38 and B.animalis BA-5 had stronger anti-aging activity in vivo.关键词
双歧杆菌/秀丽隐杆线虫/抗衰老/体内Key words
Bifidobacterium/Caenorhabditis elegans/anti-aging/in vivo分类
轻工纺织引用本文复制引用
龚春淼,王晓楠,费鹏,李岩,赵小萌,段泊安,陈树兴..4株双歧杆菌对秀丽隐杆线虫的体内抗衰老作用[J].食品科学,2024,45(13):146-152,7.基金项目
北京市科技计划项目(Z201100008020005) （Z201100008020005）
