食品与发酵工业2024，Vol.50Issue(13)：39-46,8.DOI:10.13995/j.cnki.11-1802/ts.038750
卡拉胶寡糖对秀丽隐杆线虫的抗衰老作用研究
Anti-aging effect of carrageenan oligosaccharides on Caenorhabditis elegans
摘要
Abstract
This study aimed to explore the anti-aging ability of carrageenan oligosaccharides based on the biobeauty Caenorhabditis el-egans model.Nematodes were fed with Escherichia coli solution containing different concentrations(0,0.25,0.50,1.00 mg/mL)of car-rageenan oligosaccharides.The study observed the effects of carrageenan oligosaccharides on nematode longevity,fecundity,body length,body width,lipofuscin,exercise capacity,and heat stress capacity and measured the reactive oxygen species(ROS)content and antioxi-dant enzyme activity in nematodes,investigating the effect of carrageenan oligosaccharides on anti-aging in nematodes.Compared with the control group,all concentrations of carrageenan oligosaccharide(KCO-5)with a molecular weight of 1.58 kDa could prolong the lifespan of nematodes and could extend the lifespan of nematodes by 4.18％-16.48％.It improved the body length,width,locomotion and stress capacity of nematodes,reduced the level of lipofuscin accumulation in the body,and did not impair reproductive ability.KCO-5 signifi-cantly reduced the content of ROS and malondialdehyde in nematodes and increased the activities of superoxide dismutase,catalase,and glutathione in a dose-dependent manner(P＜0.05).Results showed that KCO-5 neutralized the excess ROS,enhanced the stress resist-ance of nematodes,and extended the lifespan.In summary,carrageenan oligosaccharides have anti-aging benefits and are a new possible source of functional food or drug alternatives for reducing oxidative stress and improving a healthy lifespan.关键词
卡拉胶寡糖/秀丽隐杆线虫/抗衰老/抗氧化/健康寿命Key words
carrageenan oligosaccharides/Caenorhabditis elegans/anti-aging/antioxidant/healthy life expectancy引用本文复制引用
黎梓玉,宋兵兵,潘明雪,袁媛,陈菁,汪卓,张杰良,钟赛意..卡拉胶寡糖对秀丽隐杆线虫的抗衰老作用研究[J].食品与发酵工业,2024,50(13):39-46,8.基金项目
广东省高校生物医药健康重点领域专项资金项目(2023ZDZX2025) （2023ZDZX2025）
广东海洋大学优秀学位论文培育项目(202318) （202318）
广东海洋大学大学生创新团队项目(CXTD2023005) （CXTD2023005）
广东省高校创新团队计划项目(2021KCXTD021) （2021KCXTD021）
