卡拉胶寡糖对秀丽隐杆线虫的抗衰老作用研究OA北大核心CSTPCD

This study aimed to explore the anti-aging ability of carrageenan oligosaccharides based on the biobeauty Caenorhabditis el-egans model.Nematodes were fed with Escherichia coli solution containing different concentrations(0,0.25,0.50,1.00 mg/mL)of car-rageenan oligosaccharides.The study observed the effects of carrageenan oligosaccharides on nematode longevity,fecundity,body length,body width,lipofuscin,exercise capacity,and heat stress capacity and measured the reactive oxygen species(ROS)content and antioxi-dant enzyme activity in nematodes,investigating the effect of carrageenan oligosaccharides on anti-aging in nematodes.Compared with the control group,all concentrations of carrageenan oligosaccharide(KCO-5)with a molecular weight of 1.58 kDa could prolong the lifespan of nematodes and could extend the lifespan of nematodes by 4.18％-16.48％.It improved the body length,width,locomotion and stress capacity of nematodes,reduced the level of lipofuscin accumulation in the body,and did not impair reproductive ability.KCO-5 signifi-cantly reduced the content of ROS and malondialdehyde in nematodes and increased the activities of superoxide dismutase,catalase,and glutathione in a dose-dependent manner(P＜0.05).Results showed that KCO-5 neutralized the excess ROS,enhanced the stress resist-ance of nematodes,and extended the lifespan.In summary,carrageenan oligosaccharides have anti-aging benefits and are a new possible source of functional food or drug alternatives for reducing oxidative stress and improving a healthy lifespan.