食品与发酵工业2024，Vol.50Issue(13)：55-63,71,10.DOI:10.13995/j.cnki.11-1802/ts.036456
黄精乌鸡膏营养组分及其对不同免疫状态小鼠肠道黏膜形态和免疫性能的影响
Nutritional composition of jellied black-bone chicken with Rhizoma polygonati and its effects on intestinal mucosal morphology and immunity of mice in different immunologic status
摘要
Abstract
To explore the nutrition composition and immunomodulating activity of jellied black-bone chicken with Rhizoma polygonati(JBR),this study analyzed the nutritive components and functional substance of JBR by using the metabonomic method.And then,this study studied the regulatory effects of JBR on bodyweight,intestinal mucosa morphology,and immunological function of C57BL/6 mice in different immunologic status.Results showed that in comparison to jellied black-bone chicken(JB),the contents of several kinds of essen-tial amino acids,carbohydrates,and flavor substances were significantly higher in JBR.Results of KEGG pathway enrichment found that JBR had a potential biological function of regulating nutrient metabolism and immunity.Results of animal experiments revealed that JBR significantly improved the intestinal mucosal morphology of mice treated with cyclophosphamide and LPS.And so,JBR could significantly alleviate the bodyweight loss caused by cyclophosphamide.Besides,JBR significantly inhibited the hyperexpression of splenic NF-κB in-duced by cyclophosphamide+LPS,as well as reduced the level of TNF-α in both the spleen and serum.This indicated that JBR could suppress the inflammatory response induced by cyclophosphamide+LPS,which further relieved the inflammation-induced splenic tissue injury.Results of splenic lymphocyte proliferation,NK cell activity,and HC50 all indicated that JBR could significantly enhance the im-munity of immunosuppressed mice,as well as restrain the cyclophosphamide+LPS-induced immune abnormalities.JBR could modulate the biological status of nutrition metabolism and immunity.And so,JBR has improved effects on intestinal mucosa morphology and immu-nity of immunosuppressed mice,which is helpful for immunosuppressed mice to deal with LPS-induced acute inflammation,as well as re-ducing the inflammatory tissue damage in the spleen.关键词
黄精乌鸡膏/代谢组/C57BL/6小鼠/肠道黏膜形态/免疫功能Key words
jellied black-bone chicken with Rhizoma polygonati/metabolome/C57BL/6 mice/intestinal mucosal morphology/immunologi-cal function引用本文复制引用
张敏,冯景,刘喆,李玉龙..黄精乌鸡膏营养组分及其对不同免疫状态小鼠肠道黏膜形态和免疫性能的影响[J].食品与发酵工业,2024,50(13):55-63,71,10.基金项目
略阳乌鸡产业发展研究院项目(WJYJY-2021-10) （WJYJY-2021-10）
