西安交通大学学报（医学版）2024，Vol.45Issue(4)：525-534,10.DOI:10.7652/jdyxb202404001
结直肠癌的共识分子分型及其临床应用展望
Consensus molecular subtype of colorectal cancer and its clinical application prospects
摘要
Abstract
Colorectal cancer(CRC)is highly heterogeneous,but traditional TNM staging cannot distinguish the heterogeneity of CRC well,which can no longer meet the treatment needs.Integrating the clinical features,molecular genetic changes in cancer tissue,transcriptome and proteome changes,as well as immune matrix characteristics,the consensus molecular subtype(CMS)of CRC is by far the best description of its heterogeneity.This paper first discusses the molecular genetic changes of three types of CRC cancer tissues(chromosomal instability,microsatellite instability,and CpG island methylation phenotype).Then it systematically elaborates on the clinical characteristics,treatment directions,and prognosis evaluation of CRC patients with different CMS subtypes,as well as their relationship with immunotherapy and changes in gut microbiota.With the continuous improvement of sequencing technology and the prospective precision medicine clinical trial exploration,the"multi-molecule multi-drug"treatment model based on CMS typing will become the core of future precision medicine and personalized medicine.关键词
结直肠癌(CRC)/异质性/共识分子分型(CMS)/临床应用Key words
colorectal cancer(CRC)/heterogeneity/consensus molecular subtype(CMS)/clinical application分类
医药卫生引用本文复制引用
靳天乐,刘雨泉,王润石,侯妮,李杰..结直肠癌的共识分子分型及其临床应用展望[J].西安交通大学学报（医学版）,2024,45(4):525-534,10.基金项目
陕西省重点研发计划国际科技合作计划项目(No.2021KW-59) （No.2021KW-59）
西安交通大学医学部基础-临床融合创新项目(No.YXJLRH2022083)Supported by the Key Research and Development Plan of Shaanxi Province(No.2021KW-59)and Xi'an Jiaotong University Health Science Center Basic-Clinical Fusion Innovation Project(No.YXJLRH2022083) （No.YXJLRH2022083）
