协和医学杂志2024，Vol.15Issue(4)：734-739,6.DOI:10.12290/xhyxzz.2024-0386
注重从基础研究中汲取胰腺神经内分泌肿瘤诊疗的新思路
Deriving New Ideas for the Diagnosis and Treatment of Pancreatic Neuroendocrine Neoplasms from Basic Research
摘要
Abstract
Pancreatic neuroendocrine neoplasm(pNEN)is the most common neuroendocrine tumor in the digestive system.The heterogeneity of pNEN makes it difficult to summarize diagnostic and therapeutic strat-egies only based on clinical experience.Over the past 20 years,basic research on pNEN has been well devel-oped,which in turn has promoted its theoretical system and diagnostic and therapeutic strategies,significantly improving the therapeutic efficacy of pNEN.In this paper,we review the development of basic research on pNEN in recent years and discuss its role in clinical diagnosis and treatment.On the one hand,the development of basic research can further reveal the nature of the differential biological behavior of pNEN and provide clini-cal reference;on the other hand,reference to the migratory basic research results in other tumor fields is also conducive to improving the clinical diagnosis and treatment level of pNEN.关键词
胰腺神经内分泌肿瘤/精准诊疗/肿瘤类器官/液体活检/影像组学/免疫治疗Key words
pancreatic neuroendocrine neoplasm/precision medicine/tumor organoid/liquid biopsy/radiomics/immunotherapy分类
医药卫生引用本文复制引用
王先泽,平陆,吴文铭..注重从基础研究中汲取胰腺神经内分泌肿瘤诊疗的新思路[J].协和医学杂志,2024,15(4):734-739,6.基金项目
National Natural Science Foundation of China(82141102) （82141102）
National High Level Hospital Clinical Research Fun-ding(2022-PUMCH-A-134) 国家自然科学基金(82141102) （2022-PUMCH-A-134）
中央高水平医院临床科研专项(2022-PUMCH-A-134) （2022-PUMCH-A-134）
