中国动脉硬化杂志2024，Vol.32Issue(7)：613-620,8.DOI:10.20039/j.cnki.1007-3949.2024.07.009
m6A甲基化在心肌梗死后心肌重构发病机制中的研究进展
Research progress in the role of m6A methylation in the pathogenesis of myocardial remodeling after myocardial infarction
摘要
Abstract
Myocardial infarction is the most common cause of heart failure,and myocardial remodeling can occur after infarction,thus contributing to the progression of heart failure.The occurrence of post-infarction ventricular remode-ling is closely related to m6A methylation.m6A methylation is a reversible and highly dynamic process.This process is mainly mediated by m6A methylation positive and negative regulatory enzymes and is involved in the occurrence of post-in-farction myocardial remodeling through mechanisms such as cellular autophagy.This article mainly reviews relevant litera-ture in recent years.Firstly,a brief introduction is given to m6A methylation,followed by an introduction to the role of m6A methylase in regulating myocardial remodeling.Finally,a summary analysis is conducted on the mechanism of m6A methylation in regulating myocardial remodeling from the perspectives of autophagy,inflammation,cell apoptosis,calcium ion homeostasis,extracellular matrix remodeling,and ferroptosis.The feasibility of using m6A methylation serological de-tection as a diagnostic tool for myocardial remodeling after myocardial infarction is discussed,in order to provide reference for related research.关键词
m6A甲基化/心肌梗死/心肌重构/心力衰竭Key words
m6A methylation/myocardial infarction/myocardial remodeling/heart failure分类
医药卫生引用本文复制引用
解长旭,郭帅杰,陈思琪,张蕾,刘卫红,李思耐,周明学..m6A甲基化在心肌梗死后心肌重构发病机制中的研究进展[J].中国动脉硬化杂志,2024,32(7):613-620,8.基金项目
国家自然科学基金项目(82274287) （82274287）
北京市自然科学基金项目(7232266) （7232266）
