中国人兽共患病学报2024，Vol.40Issue(6)：571-577,7.DOI:10.3969/j.issn.1002-2694.2024.00.089
河弧菌Ⅵ型分泌系统组成、功能及调控研究进展
The structure,function and regulation mechanism of Vibrio fluvialis Type Ⅵ secretion system
摘要
Abstract
Type Ⅵ secretion system(T6SS)is a lethal weapon that releases effectors in direct contact to kill eukaryotic predators or prokaryotic competitors.T6SS is of great significance in bacterial environmental adaptability,pathogenicity,and gene horizontal transfer.T6SS has been identified in about 25％of Gram-negative bacteria.Because of its widespread existence,T6SS is considered the key factor of ecological competition.T6SS effectors exerting biological functions have high diversity and do not have conserved sequences,and the regulatory mechanisms involved are complex.Therefore,it is a hot and difficult topic in T6SS research.Vibrio fluvialis(V.fluvialis)as a newly emerging foodborne pathogen,has unique characteristics in the quantity,composition,and physiological function of T6SS,which is related to its wide environmental adaptability and pathoge-nicity.This article mainly reviews the research progress of V.fluvialis T6SS,including its composition,structure,functional activity,and regulatory mechanism.关键词
Ⅵ型分泌系统/河弧菌/效应蛋白/弧菌属Key words
Type Ⅵ secretion system/Vibrio fluvialis/effector/Vibrio分类
医药卫生引用本文复制引用
韩雨,冀赛森,程倩,黄元铭,段然,梁未丽..河弧菌Ⅵ型分泌系统组成、功能及调控研究进展[J].中国人兽共患病学报,2024,40(6):571-577,7.基金项目
Supported by the National Natural Science Foundation of China(No.81772242)and the National Key R&D Program of China(No.2021YFC2300302) 国家自然科学基金(No.81772242)和国家重点研发计划(No.2021YFC2300302)联合资助 （No.81772242）
