中国人兽共患病学报2024，Vol.40Issue(6)：590-594,598,6.DOI:10.3969/j.issn.1002-2694.2024.00.081
福建省3例输入性白喉棒状杆菌感染病例流行病学和病原学分析
Epidemiological and pathogenic analyses of three cases of imported Corynebacterium diphtheriae infection in Fujian Province
摘要
Abstract
The epidemiology and etiology of three suspected cases of imported skin diphtheria infection in Fujian Province were investigated.Secretion samples of patients with skin damage were collected for isolation and culture of Corynebacterium diphtheriae.Biochemical identification and mass spectrum analysis of pure cultures of suspected C.diphtheriae were conduc-ted,the virulence-related genes,including diphtheria toxin reporter(dtxR),toxin A(toxA),and toxin B(toxB)were detec-ted,and multilocus sequence typing(MLST)was performed.All three cases had typical clinical manifestations of cutaneous diphtheria,and C.diphtheriae was isolated from the damaged skin.The virulence genes of two C.diphtheriae strains isolated from two cases were identified as dtxR(+),toxA(-),and toxB(-),and the MLST type was ST-703.The virulence genes of C.diphtheriae isolated from one case were identified as dtxR(+),toxA(+),toxB(+),and the MLST type was ST-248.There is an increased risk of diphtheria in Fujian Province.C.diphtheriae without diphtheria toxin genes can also cause skin diphtheria.关键词
白喉棒状杆菌/毒力基因/皮肤白喉Key words
Corynebacterium diphtheriae/virulence gene/cutaneous diphtheria分类
医药卫生引用本文复制引用
李曲文,梁雪晨,高亚东,翁顺太,高源,邵祝军..福建省3例输入性白喉棒状杆菌感染病例流行病学和病原学分析[J].中国人兽共患病学报,2024,40(6):590-594,598,6.基金项目
福建省卫生健康科技计划项目(No.2021GGA036)和福建省科技创新平台建设项目(No.2019Y2001)联合资助 Supported by the Fujian Provincial Health Science and Tech-nology Plan Project support(No.2021GGA036),and the Fujian Provincial Science and Technology Innovation Platform construction project(No.2019Y2001). （No.2021GGA036）
