中国药理学通报2024，Vol.40Issue(8)：1413-1418,6.DOI:10.12360/CPB202305040
纳米氧化石墨烯作为临床药物载体在肿瘤治疗中的研究
Development of nanographene oxide as clinical drug carrier in cancer therapy
摘要
Abstract
Immunotherapy is an important breakthrough in canc-er treatment.Unfortunately,low drug concentration in tumor sites almost ineffectively initiates immune responses and thereby severely limits immune therapy applications in clinics.Nanoma-terials are well-recognized drug delivery system in cancer thera-py.Nanographene oxide(NGO)have shown immense perti-nence for anti-cancer drug delivery owing to their ultra-high sur-face area,chemical stability,good biocompatibility and excel-lent photosensitivity.In addition,functionalized modifications on the surface of NGO increase tumor targeting and minimize cy-totoxicity.This study focuses on reviewing the literature and up-dates on NGO in drug delivery and discussing the possibilities and challenges of NGO in cancer synergetic therapy.关键词
癌症治疗/纳米氧化石墨烯/药物装载/靶向输送/光热治疗/联合治疗Key words
cancer therapy/nanographene oxide/drug load-ing/targeted delivery/photothermal therapy/combination thera-py分类
医药卫生引用本文复制引用
钟春莲,方昌建,周桂羽,朱慧玲,郑镗,庄婉晶,刘剑,卢余盛..纳米氧化石墨烯作为临床药物载体在肿瘤治疗中的研究[J].中国药理学通报,2024,40(8):1413-1418,6.基金项目
国家自然科学基金资助项目(No 82104406) （No 82104406）
福建省级大学生创新创业训练计划(No S202210395056) （No S202210395056）
