中国药理学通报2024，Vol.40Issue(8)：1418-1423,6.DOI:10.12360/CPB202403077
代谢重编程在心力衰竭中的研究进展
Advances in metabolic reprogramming in heart failure
摘要
Abstract
Adenosine triphosphate(ATP)production in cardio-myocytes in healthy heart depends primarily on the oxidative phosphorylation of fatty acids and,to a lesser extent,on the oxi-dation or glycolysis of glucose.Patients with heart failure devel-op severe disturbances in energy metabolism,including disturb-ances in substrate uptake and utilization,oxidative phosphoryla-tion,and ATP shuttling,resulting in inadequate cardiac energy supply.By intervening in energy metabolism pathways,cardiac efficiency can be increased,energy production deficits can be reduced,and cardiac function can be improved in patients with heart failure.We hence have reviewed and outlined the mecha-nisms and therapeutic implications of metabolic changes during heart failure.关键词
心力衰竭/代谢重编程/脂肪酸代谢/葡萄糖/酮体/线粒体Key words
heart failure/metabolic reprogramming/lipid me-tabolism/glucose/ketone bodies/mitochondria分类
医药卫生引用本文复制引用
黄磊,李文文,翁培文,高杉..代谢重编程在心力衰竭中的研究进展[J].中国药理学通报,2024,40(8):1418-1423,6.基金项目
国家自然科学基金资助项目(No 81873126) （No 81873126）
