养心定悸胶囊治疗快速性心律失常的Meta分析和成本-效果OA

Objective To compare the clinical efficacy and economy of Yangxin Dingji capsule combined with conventional western medicine therapy and conventional western medicine therapy in the treatment of tachyarrhythmia.Methods A Meta-analysis was made on the treatment of tachyarrhythmia by Yangxin Dingji capsule combined with conventional western medicine therapy and conventional western medicine therapy.A decision tree model is established to carry out cost-effectiveness analysis from the perspective of medical system.Efficacy parameter was clinical effective rate derived from clinical literature meta-analysis,cost parameter was drug treatment cost,incremental cost-effectiveness ratio(ICER)was calculated,and the stability of basic analysis results was tested by single factor sensitivity analysis.Results The results of Meta-analysis showed that when the course of treatment was 8 weeks,compared with conventional western medicine therapy,the clinical efficacy of Yangxin Dingji capsule combined with conventional western medicine therapy treating tachyarrhythmia was better,and the difference was statistically significant[OR=3.32,95%CI(2.22～4.96),P＜0.000 01];When the course of treatment was 4 weeks,the clinical efficacy of Yangxin Dingji capsule combined with conventional western medicine therapy treating tachyarrhythmia was better,and the difference was statistically significant[OR=2.39,95%CI(1.45～3.96),P=0.000 7].The cost-effectiveness analysis showed that when the course of treatment was 8 weeks,the clinical effective rate of Yangxin Dingji capsule combined with conventional western medicine therapy in the treatment of arrhythmia increased by 1%,and the cost increased by 91.78 yuan;When the course of treatment was 4 weeks,the clinical effective rate of Yangxin Dingji capsule combined with conventional western medicine therapy in the treatment of arrhythmia increased by 1%and the cost increased by 70.84 yuan.One-way sensitivity analysis showed that the results were robust.Conclusion In the treatment of tachyarrhythmia,the clinical efficacy of Yangxin Dingji capsule combined with conventional western medicine therapy is superior to that of conventional western medicine therapy.When the willingness to pay value is greater than the corresponding ICER value,Yangxin Dingji capsule combined with conventional western medicine therapy is more economical than conventional western medicine therapy.