临床药师参与137例儿童活体肝移植多学科会诊效果分析OACSTPCD

Objective To improve the effectiveness and safety of pediatric living liver transplantation.Methods The medical records of children underwent the living liver transplantation and received multi-disciplinary treatment(MDT)in the hospital from July 2017 to December 2023 were collected.The children's basic information,perioperative use of anti-infective drugs,pathogen examination,purpose of clinical pharmacists participating in MDT,adoption of consultation recommendations and children's disease outcomes were extracted and analyzed.Results A total of 137 children were included,who underwent 154 case times of MDT,with clinical pharmacists participating in 141 case times.The children were mainly in the range of>six months to one year(68 case times,32.85% ),and the main primary disease was biliary atresia(96 case times,70.07% ).The staff in the organ transplantation department(154 case times,100.00% ),pediatrics(147 case times,95.45% )and pediatric intensive care unit(142 case times,92.21% )participated more in pediatric MDT.The purpose of clinical pharmacists participating in MDT was mainly to guide the selection/adjustment of anti-infective drugs(112 case times,79.43% ).The early postoperative pathogen examination in 31 children was positive,and 54 strains of pathogenic bacteria were detected,in which the detection rate of Gram-negative bacteria was the highest(31 strains,57.41% ),and the main anti-infective drug was cefoperazone and sulbactam(1∶1,68 cases,49.64% ).The overall adoption rate of clinical pharmacists' opinions was 83.69%,with a cure rate of 42.37% .Conclusion The clinical pharmacists' participation in MDT can provide professional pharmaceutical recommendations for individualized medication in children undergoing living liver transplantation and further ensure the effectiveness and safety of treatment.