甘草油治疗糖尿病足植皮术后伤口的临床研究OACSTPCD

Objective:To observe the clinical effect of traditional Chinese medicine(TCM)external preparation licorice oil in the treatment of wounds after diabetic foot skin grafting.Methods:Sixty patients with diabetic foot wounds after skin grafting were randomly divided into two groups according to a random number table.In the control group,30 patients were treated with mupirocin gauze for wound dressing,while in the treatment group,30 patients were treated with topical licorice oil for wound dressing.The efficacy,graft survival rate on the 3rd postoperative day,wound healing rate on the 7th postoperative day,and pain during the first three dressing changes were observed in both groups.Additionally,changes in the levels of matrix metalloproteinase-2(MMP-2)and matrix metalloproteinase inhibitor-1(TIMP-1),in wound exudate were analyzed on the day before surgery,the 3rd postoperative day,and the 7th postoperative day.Results:The treatment group showed a graft survival rate of 85.0%on the 3rd postoperative day and a wound healing rate of 90.0%on the 7th postoperative day,both significantly higher than 60.0%and 52.5%in the control group(P<0.05).Pain scores during the first three dressing changes were significantly lower in the treatment group than in the control group(P<0.05).On the 3rd postoperative day,the MMP-2 concentration in wound exudate in the treatment group was(15.87±5.22)ng·mL-1,and on the 7th postoperative day,it was(9.36±1.97)ng·mL-1,both significantly lower than those in the control group(P<0.05).The TIMP-1 levels in wound exudate in the treatment group were(26.36±4.16)ng·mL-1 on the 3rd postoperative day and(35.37±5.81)ng·mL-1 on the 7th postoperative day,both significantly higher than those in the control group(P<0.05).Conclusion:External application of licorice oil is effective in treating wounds after skin grafting in diabetic foot patients,which can improve the expression of wound inflammation factors and promote wound healing.