基于PI3K/Akt途径探讨溃疡性结肠炎发病机制及中药干预作用研究进展OACSTPCD

Ulcerative colitis(UC)is a nonspecific inflammatory disease characterized by persistent mucosal inflammation,and its incidence is on the rise worldwide.However,the exact pathogenesis of UC is not yet clear,and it is generally believed that the pathogenesis of UC is related to intestinal microbiota dysbiosis,host immune response,genetics,and environment.Phosphatidylinositol-3-hydroxykinase(PI3K)/protein kinase B(Akt)is closely related to biological processes such as cell survival,apoptosis,and inflammation.Numerous studies have shown that the PI3K/Akt signaling pathway is involved in the process of UC occurrence and development.In recent years,researchers have conducted a large number of clinical experimental studies on the basis of PI3K/Akt signalling pathway with Chinese herbal medicine formulae,traditional Chinese medicinals and active ingredients of the medicinals and formulae.The results have shown that the PI3K/Akt signalling pathway is expected to be a potential therapeutic target for UC.Based on this,this article reviews the recent domestic and international studies on the role of Chinese herbal medicine in regulating the PI3K/Akt signalling pathway in the pathogenesis and treatment of UC,with the aim of providing certain references and bases for the clinical targeted diagnosis and treatment of UC.