首页|期刊导航|Neural Regeneration Research|Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegia
Targeting cholesterol trafficking to mitigate axonal degeneration in hereditary spastic paraplegiaOA
Axonal degeneration underlies many debilitating diseases including hereditary spastic paraplegia(HSP),a genetically and clinically diverse group of disorders characterized by spasticity and weakness of the lower extremities.HSP is one significant cause of chronic neurodisability due to the lack of effective treatments and a wide range of onset ages from early childhood to 70 years.
Zhenyu Chen;Xue-Jun Li;
Department of Biomedical Sciences,University of Illinois College of Medicine Rockford,Rockford,IL,USA Department of Bioengineering,University of Illinois at Chicago,Chicago,IL,USA
临床医学
degenerationdiseaseshereditary
《Neural Regeneration Research》 2025 (005)
P.1397-1398 / 2
supported by the NIH grant(RO1 NS118066);the Blazer Foundation(to XJL)。
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